DU Hong-Xia, Hu Yuan-Yuan
Department of Dermatology, Xinyang Central Hospital,Xinyang,Henan 464000,China.
Department of Medical Cosmetology,Xinyang Central Hospital,Xinyang,Henan 464000,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Apr;44(2):208-212. doi: 10.3881/j.issn.1000-503X.13708.
Objective To study the influence of recombinant bovine basic fibroblast growth factor as an adjuvant therapy on scar alleviation and inflammatory cytokines in patients with atrophic acne scar. Methods The random number table was employed to randomly assign 120 patients with atrophic acne scar into a test group and a control group.Both groups of patients were treated with CO lattice laser.After the operation,the control group was routinely smeared with erythromycin ointment and the test group was coated with recombinant bovine basic fibroblast growth factor gel.The clinical efficacy,clinical indicators,scar alleviation,and inflammatory cytokine levels before and after treatment were compared,and adverse reactions were counted. Results The test group had higher total effective rate(=0.040) and lower total incidence of adverse reactions(=0.028) than the control group.Compared with the control group,the test group showcased short erythema duration after treatment(=0.025),early scab forming(=0.002),and early edema regression(<0.001).After treatment,the proportion of grade 1 scars graded by Goodman and Baron's acne scar grading system in the test group and control group increased(=0.001,=0.027),and the proportion of grade 4 scars decreased(<0.001,=0.034).Moreover,the proportion of grade 1 scars in the test group was higher than that in the control group(=0.031) after treatment,and the proportion of grade 4 scars presented an opposite trend(=0.031).After treatment,the levels of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in both groups declined(all <0.001),and the test group had lower TNF-α and IL-1β levels than the control group(all <0.001). Conclusion The recombinant bovine basic fibroblast growth factor gel as an adjuvant therapy of CO lattice laser can effectively alleviate the atrophic acne scar,relieve local inflammatory reaction,and has good curative effect and less adverse reactions.
目的 探讨重组牛碱性成纤维细胞生长因子作为辅助治疗对萎缩性痤疮瘢痕患者瘢痕减轻及炎性细胞因子的影响。方法 采用随机数字表法将120例萎缩性痤疮瘢痕患者随机分为试验组和对照组。两组患者均接受CO2点阵激光治疗。术后，对照组常规涂抹红霉素软膏，试验组涂抹重组牛碱性成纤维细胞生长因子凝胶。比较两组治疗前后的临床疗效、临床指标、瘢痕减轻情况及炎性细胞因子水平，并统计不良反应。结果 试验组总有效率高于对照组（P = 0.040），不良反应总发生率低于对照组（P = 0.028）。与对照组相比，试验组治疗后红斑持续时间短（P = 0.025）、结痂早（P = 0.002）、水肿消退早（P < 0.001）。治疗后，试验组和对照组采用Goodman和Baron痤疮瘢痕分级系统评定的1级瘢痕比例均升高（P = 0.001，P = 0.027），4级瘢痕比例均降低（P < 0.001，P = 0.034）。且治疗后试验组1级瘢痕比例高于对照组（P = 0.031），4级瘢痕比例呈相反趋势（P = 0.031）。治疗后，两组肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平均下降（均P < 0.001），且试验组TNF-α和IL-1β水平低于对照组（均P < 0.001）。结论 重组牛碱性成纤维细胞生长因子凝胶作为CO2点阵激光的辅助治疗，可有效减轻萎缩性痤疮瘢痕，缓解局部炎症反应，疗效好且不良反应少。
