KLF4表达失调在胰腺导管内乳头状黏液性肿瘤的发病机制中起关键作用。 - Suppr

Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms.

作者信息

Zuo Xiangsheng, Wang Liang, Liu Yi, Wang Huamin, Hafley Margarete, Gagea Mihai, Chen Ru, Xiong Yun, Pan Sheng, Shureiqi Imad, Bresalier Robert S, Wei Daoyan

机构信息

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Gut. 2025 Jan 17;74(2):327-329. doi: 10.1136/gutjnl-2024-332255.

DOI:10.1136/gutjnl-2024-332255

PMID:38969489

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11874310/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa4/11874310/79e68973da12/gutjnl-74-2-g001.jpg

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Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms.KLF4表达失调在胰腺导管内乳头状黏液性肿瘤的发病机制中起关键作用。

Gut. 2025 Jan 17;74(2):327-329. doi: 10.1136/gutjnl-2024-332255.

Identification of Small Proteins and Peptides in the Differentiation of Patients with Intraductal Mucinous Neoplasms of the Pancreas, Chronic Pancreatitis and Pancreatic Adenocarcinoma.鉴定胰腺导管内黏液性肿瘤、慢性胰腺炎和胰腺腺癌患者分化过程中的小蛋白和肽。

Dig Dis Sci. 2018 Apr;63(4):920-933. doi: 10.1007/s10620-018-4944-4. Epub 2018 Feb 8.

Concomitant intraductal papillary mucinous neoplasm and pancreatic endocrine tumour: Report of two cases and review of the literature.导管内乳头状黏液性肿瘤与胰腺内分泌肿瘤并存：两例报告及文献复习

Dig Liver Dis. 2009 Oct;41(10):759-61. doi: 10.1016/j.dld.2009.01.005. Epub 2009 Feb 14.

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic mutations predominantly in low-grade regions.多区域胰管内乳头状黏液性肿瘤全外显子组测序揭示低级别区域频繁发生体细胞突变。

Gut. 2021 May;70(5):928-939. doi: 10.1136/gutjnl-2020-321217. Epub 2020 Oct 7.

The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.嗜酸性细胞亚型在基因上与其他胰腺导管内乳头状黏液性肿瘤亚型不同。

Mod Pathol. 2016 Sep;29(9):1058-69. doi: 10.1038/modpathol.2016.98. Epub 2016 Jun 10.

Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.涉及双特异性磷酸酶6/丝裂原活化蛋白激酶磷酸酶-3（DUSP6/MKP-3）功能障碍的不同进展途径在胰腺上皮内瘤变和胰腺导管内乳头状黏液性肿瘤中的作用。

Mod Pathol. 2005 Aug;18(8):1034-42. doi: 10.1038/modpathol.3800383.

Intraductal papillary mucinous neoplasm.导管内乳头状黏液性肿瘤。

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Adenosquamous carcinoma coexisting with intraductal papillary mucinous neoplasm of the pancreas: a case report.胰腺腺鳞癌合并胰腺导管内乳头状黏液性肿瘤：一例报告。

J Med Case Rep. 2023 Mar 2;17(1):72. doi: 10.1186/s13256-023-03798-0.

Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas.CD24 在胰腺导管内乳头状黏液性肿瘤和导管腺癌中的表达特征。

Hum Pathol. 2010 Oct;41(10):1466-74. doi: 10.1016/j.humpath.2010.04.004.

Expression of claudin-4 (CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas.Claudin-4（CLDN4）mRNA 在胰腺导管内乳头状黏液性肿瘤中的表达。

Mod Pathol. 2011 Apr;24(4):533-41. doi: 10.1038/modpathol.2010.218. Epub 2010 Nov 19.

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KLF4 promotes cisplatin resistance by activating mTORC1 signaling in ovarian cancer.KLF4通过激活卵巢癌中的mTORC1信号通路促进顺铂耐药。

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Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential.胰腺导管内乳头状黏液性肿瘤的空间转录组学鉴定 NKX6-2 为胃分化和惰性生物学潜能的驱动因素。

Cancer Discov. 2023 Aug 4;13(8):1844-1861. doi: 10.1158/2159-8290.CD-22-1200.

Gut. 2021 May;70(5):928-939. doi: 10.1136/gutjnl-2020-321217. Epub 2020 Oct 7.

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis.KLF4 对于早期胰腺癌发生过程中细胞身份改变和腺泡到导管重编程的诱导至关重要。

Cancer Cell. 2016 Mar 14;29(3):324-338. doi: 10.1016/j.ccell.2016.02.005.

KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis.KLF4介导的CD44信号抑制对胰腺癌干性和转移产生负面影响。

Cancer Res. 2016 Apr 15;76(8):2419-31. doi: 10.1158/0008-5472.CAN-15-1691. Epub 2016 Feb 15.

SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms.SOX9：一种用于胰腺肿瘤导管谱系的有用标志物。

Hum Pathol. 2014 Mar;45(3):456-63. doi: 10.1016/j.humpath.2013.10.008. Epub 2013 Oct 19.

Critical lysine residues of Klf4 required for protein stabilization and degradation.Klf4 蛋白稳定和降解所需的关键赖氨酸残基。

Biochem Biophys Res Commun. 2014 Jan 24;443(4):1206-10. doi: 10.1016/j.bbrc.2013.12.121. Epub 2014 Jan 2.

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.鉴定 Sox9 依赖性的腺泡到导管重编程作为胰腺导管腺癌起始的主要机制。

Cancer Cell. 2012 Dec 11;22(6):737-50. doi: 10.1016/j.ccr.2012.10.025. Epub 2012 Nov 29.

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.Sox9+ 导管细胞在整个发育过程中都是多能祖细胞，但在正常或受伤的成年胰腺中不会产生新的内分泌细胞。

Development. 2011 Feb;138(4):653-65. doi: 10.1242/dev.056499.

Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells.Kruppel样因子4诱导人胰腺癌细胞中p27Kip1的表达并抑制其生长和转移。

Cancer Res. 2008 Jun 15;68(12):4631-9. doi: 10.1158/0008-5472.CAN-07-5953.

Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway.响应血清刺激时，Krüppel样因子4蛋白的稳定性破坏涉及泛素-蛋白酶体途径。

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Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms.

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