急性心力衰竭患者非侵入性低强度耳屏刺激后的血压变异性
Blood Pressure Variability After Non-invasive Low-level Tragus Stimulation in Acute Heart Failure.
作者信息
Nagai Michiaki, Dote Keigo, Kato Masaya, Sasaki Shota, Oda Noboru, Po Sunny S, Dasari Tarun W
机构信息
Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan.
Cardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
出版信息
J Cardiovasc Transl Res. 2024 Dec;17(6):1347-1352. doi: 10.1007/s12265-024-10544-4. Epub 2024 Jul 5.
Higher blood pressure (BP) variability (BPV) was shown to be strong predictors of poor cardiovascular outcomes in heart failure (HF). It is currently unknown if low-level tragus stimulation (LLTS) would lead to improvement in BPV in acute HF (AHF). The 22 patients with AHF (median 80 yrs, males 60%) were randomly assigned to active or sham group using an ear clip attached to the tragus (active group) or the earlobe (sham group) for 1 h daily over 5 days. In the active group, standard deviation (SD), coefficient of variation (CV) and δ in SBP were significantly decreased after LLTS (all p < 0.05). All the changes in SD, CV and δ in SBP before and after stimulation were also significantly different between active and sham groups (all p < 0.05). This proof-of-concept study demonstrates the beneficial effects of LLTS on BPV in AHF.
血压变异性（BPV）升高被证明是心力衰竭（HF）患者心血管不良预后的有力预测指标。目前尚不清楚低强度耳屏刺激（LLTS）是否会改善急性心力衰竭（AHF）患者的BPV。22例AHF患者（中位年龄80岁，男性占60%）被随机分为活性组或假刺激组，分别使用连接于耳屏（活性组）或耳垂（假刺激组）的耳夹，每天刺激1小时，持续5天。在活性组中，LLTS后收缩压的标准差（SD）、变异系数（CV）和δ值均显著降低（均P<0.05）。活性组和假刺激组刺激前后SBP的SD、CV和δ值的所有变化也有显著差异（均P<0.05）。这项概念验证研究证明了LLTS对AHF患者BPV的有益作用。
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