就诊间血压变异性对认知功能的影响：最新进展

The effect of visit-to-visit blood pressure variability on cognitive function: state-of the-art.

作者信息

Nagai Michiaki, Sible Isabel J, Tully Phillip J, Po Sunny S, Dasari Tarun W

机构信息

Cardiovascular section, Department of Medicine, University of Oklahoma, Health Science Center, OK, USA.

Department of Medicine, Hiroshima Asa Medical Association Hospital, Hiroshima, Japan.

出版信息

Cereb Circ Cogn Behav. 2025 Aug 5;9:100392. doi: 10.1016/j.cccb.2025.100392. eCollection 2025.

DOI:10.1016/j.cccb.2025.100392

PMID:40837525

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12362100/

Abstract

Visit-to-visit blood pressure (BP) variability (VVV) is a risk factor for cognitive impairment and cognitive decline, but several studies have recently shown that VVV also increases the risk of Alzheimer's disease (AD). Although the relationship between VVV and AD has been extensively studied, its pathophysiology is instructive due to its association with vascular stiffness, cerebral circulatory failure, decreased cardiac function, and AD pathology such as amyloid β and tau-proteins. This review article focuses on the relationship between VVV and cognitive function and summarizes recent studies and the underlying pathophysiology that appears to be mediated by systemic hemodynamic disruption.

摘要

就诊间血压（BP）变异性（VVV）是认知障碍和认知衰退的一个风险因素，但最近几项研究表明，VVV也会增加患阿尔茨海默病（AD）的风险。尽管VVV与AD之间的关系已得到广泛研究，但其病理生理学仍具有指导意义，因为它与血管僵硬、脑循环衰竭、心功能下降以及淀粉样β蛋白和tau蛋白等AD病理相关。这篇综述文章聚焦于VVV与认知功能之间的关系，并总结了近期研究以及似乎由全身血流动力学紊乱介导的潜在病理生理学。