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既往心脏手术后急性 A 型主动脉夹层的再次手术扩展弓部修复:来自一个相对年轻的再次手术系列的见解。

Reoperative extended arch repair for acute type A aortic dissection after previous cardiac surgery: insights from a relatively young redo series.

机构信息

Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Eur J Cardiothorac Surg. 2024 Jul 1;66(1). doi: 10.1093/ejcts/ezae266.

Abstract

OBJECTIVES

To evaluate the impact of previous cardiac surgery (PCS) on clinical outcomes after reoperative extended arch repair for acute type A aortic dissection.

METHODS

This study included 37 acute type A aortic dissection patients with PCS (PCS group) and 992 without PCS (no-PCS group). Propensity score-matching yielded a subgroup of 36 pairs (1:1). In-hospital outcomes and mid-term survival were compared between the 2 groups.

RESULTS

The PCS group was older (56.7 ± 14.2 vs 52.2 ± 12.6 years, P = 0.036) and underwent a longer cardiopulmonary bypass (median, 212 vs 183 min, P < 0.001) compared with the no-PCS group. Operative death occurred in 88 (8.6%) patients, exhibiting no significant difference between groups (13.5% vs 8.4%, P = 0.237). Major postoperative morbidity was observed in 431 (41.9%) patients, also showing no difference between groups (45.9% vs 41.7%, P = 0.615). Moreover, the multivariable logistic regression analysis revealed that PCS was not significantly associated with operative mortality (adjusted odds ratio 2.58, 95% confidence interval 0.91-7.29, P = 0.075) or major morbidity (adjusted odds ratio 1.92, 95% confidence interval 0.88-4.18, P = 0.101). The 3-year cumulative survival rates were 71.1% for the PCS group and 83.9% for the no-PCS group (log-rank P = 0.071). Additionally, Cox regression indicated that PCS was not significantly associated with midterm mortality (adjusted hazard ratio 1.40, 95% confidence interval 0.44-4.41, P = 0.566). After matching, no significant differences were found between groups in terms of operative mortality (P > 0.999), major morbidity (P > 0.999) and midterm survival (P = 0.564).

CONCLUSIONS

No significant differences were found between acute type A aortic dissection patients with PCS and those without PCS regarding in-hospital outcomes and midterm survival after extended arch repair.

摘要

目的

评估既往心脏手术(PCS)对急性 A 型主动脉夹层再次全弓置换术后临床结局的影响。

方法

本研究纳入 37 例有 PCS 的急性 A 型主动脉夹层患者(PCS 组)和 992 例无 PCS 的患者(无 PCS 组)。采用倾向评分匹配得到 36 对亚组(1:1)。比较两组患者的住院结局和中期生存情况。

结果

与无 PCS 组相比,PCS 组患者年龄更大(56.7±14.2 岁比 52.2±12.6 岁,P=0.036),体外循环时间更长(中位数,212 分钟比 183 分钟,P<0.001)。88 例(8.6%)患者发生围术期死亡,两组间无显著差异(13.5%比 8.4%,P=0.237)。431 例(41.9%)患者发生主要术后并发症,两组间也无差异(45.9%比 41.7%,P=0.615)。此外,多变量逻辑回归分析显示,PCS 与手术死亡率(校正比值比 2.58,95%置信区间 0.91-7.29,P=0.075)或主要并发症发生率(校正比值比 1.92,95%置信区间 0.88-4.18,P=0.101)无显著相关性。PCS 组患者的 3 年累积生存率为 71.1%,无 PCS 组为 83.9%(对数秩检验 P=0.071)。此外,Cox 回归分析显示,PCS 与中期死亡率无显著相关性(校正风险比 1.40,95%置信区间 0.44-4.41,P=0.566)。匹配后,两组患者在手术死亡率(P>0.999)、主要并发症发生率(P>0.999)和中期生存率(P=0.564)方面均无显著差异。

结论

急性 A 型主动脉夹层患者既往有心脏手术史与无心脏手术史患者行全弓置换术后,住院结局和中期生存情况无显著差异。

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