糖尿病患者糖尿病周围神经病变与心脏自主神经病变的相关性：系统评价。

The association of diabetic peripheral neuropathy with cardiac autonomic neuropathy in individuals with diabetes mellitus: A systematic review.

机构信息

Programa de Pós-Graduação em Ciências Biomédicas, Universidade Federal do Delta do Parnaíba, Parnaíba, PI, Brazil.

Curso de Bacharelado em Fisioterapia, Universidade Federal do Delta do Parnaíba, Parnaíba, PI, Brazil.

出版信息

J Diabetes Complications. 2024 Aug;38(8):108802. doi: 10.1016/j.jdiacomp.2024.108802. Epub 2024 Jun 28.

DOI:10.1016/j.jdiacomp.2024.108802

PMID:38971002

Abstract

UNLABELLED

This systematic review aimed to explore the relationship between diabetic peripheral neuropathy (DPN) and cardiac autonomic neuropathy (CAN) in individuals with type 1 and 2 diabetes mellitus (DM).

METHODS

The systematic review follow the protocol registered in Prospero (CRD42020182899). Two authors independently searched the PubMed, Scopus, Embase, Cochrane, and Web of Science databases. Discrepancies were resolved by a third author. The review included observational studies investigating the relationship between CAN and DPN in individuals with DM.

RESULTS

Initially, out of 1165 studies, only 16 were selected, with 42.8 % involving volunteers with one type of diabetes, 14.3 % with both types of diabetes and 14.3 % not specify the type. The total number of volunteers was 2582, mostly with type 2 DM. It was analyzed that there is a relationship between CAN and DPN. It was observed that more severe levels of DPN are associated with worse outcomes in autonomic tests. Some studies suggested that the techniques for evaluating DPN might serve as risk factors for CAN.

CONCLUSION

The review presents a possible relationship between DPN and CAN, such as in their severity.

摘要

目的

本系统评价旨在探讨 1 型和 2 型糖尿病患者糖尿病周围神经病变（DPN）与心脏自主神经病变（CAN）之间的关系。

方法

系统评价按照 Prospero 注册协议（CRD42020182899）进行。两位作者独立检索了 PubMed、Scopus、Embase、Cochrane 和 Web of Science 数据库。分歧由第三位作者解决。该综述纳入了观察性研究，旨在探讨糖尿病患者中 CAN 与 DPN 之间的关系。

结果

最初，在 1165 项研究中，仅选择了 16 项研究，其中 42.8%的研究涉及一种类型糖尿病的志愿者，14.3%的研究涉及两种类型糖尿病的志愿者，14.3%的研究未明确说明糖尿病的类型。志愿者总数为 2582 人，主要为 2 型糖尿病患者。分析表明 CAN 与 DPN 之间存在关系。观察到更严重程度的 DPN 与自主神经测试的预后更差相关。一些研究表明，评估 DPN 的技术可能是 CAN 的危险因素。