Columbia University Irving Medical Center, 630 W. 168th St, New York, NY 10032, United States; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, United States.
Columbia University Irving Medical Center, 630 W. 168th St, New York, NY 10032, United States; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, United States.
Drug Alcohol Depend. 2024 Sep 1;262:111375. doi: 10.1016/j.drugalcdep.2024.111375. Epub 2024 Jun 24.
Wounds are a significant source of morbidity among people who use substances (PWUS). This project sought to identify the incidence and severity of wounds among PWUS in the South Bronx, a region of New York City with one of the highest morbidities of substance use disorder.
This study recruited PWUS within the past 30 days. Research staff were trained to document the presence and severity of wounds. The primary outcome measure was the incidence of wounds. Acceptability of on-the-street wound care was assessed by the number of participants encountered. The association between participant characteristics and wounds was also evaluated.
In total, 586 PWUS were assessed (19.4 % female: 69 % Hispanic; 23 % Black; 5 % White). Heroin (65.7 %) and psychostimulants (58.3 %) were the most commonly used drugs. Approximately 23 % of outreach recipients disclosed a wound. Among those with a wound, 60.9 % reported one wound, 27.8 % had two wounds, and 11.3 % had three or more wounds. Small wounds (approximately the size of a cherry) were the most common (78.6 %). Recent use of stimulants or heroin, along with intravenous use of any substance were significantly associated with having a wound.
This study found that drug-related wounds were common among PWUS. Toxicology data from other sources indicate that xylazine was present in the NYC market at the time, though its prevalence among the current sample is difficult to determine. The occurrence and severity of substance-related wounds in NYC should continue to be monitored as a function of changes in the xylazine adulteration.
在使用物质的人群（PWUS）中，伤口是发病率的一个重要来源。本项目旨在确定在纽约市南布朗克斯区（该地区物质使用障碍发病率最高之一）的 PWUS 中伤口的发生率和严重程度。
本研究在过去 30 天内招募了 PWUS。研究人员接受了记录伤口存在和严重程度的培训。主要结局指标是伤口的发生率。通过遇到的参与者数量来评估街头伤口护理的可接受性。还评估了参与者特征与伤口之间的关联。
共评估了 586 名 PWUS（19.4%为女性：69%为西班牙裔；23%为黑人；5%为白人）。海洛因（65.7%）和苯丙胺类兴奋剂（58.3%）是最常使用的药物。大约 23%的外展对象披露了伤口。在有伤口的人中，60.9%报告有一个伤口，27.8%有两个伤口，11.3%有三个或更多伤口。小伤口（大约樱桃大小）最常见（78.6%）。最近使用兴奋剂或海洛因，以及任何物质的静脉内使用，与有伤口显著相关。
本研究发现，与药物相关的伤口在 PWUS 中很常见。来自其他来源的毒理学数据表明，当时在纽约市市场上存在苯环己哌啶，但目前样本中的流行率难以确定。随着苯环己哌啶掺假的变化，纽约市与物质相关的伤口的发生和严重程度应继续进行监测。
