VA Serious Mental Illness Treatment Resource and Evaluation Center, Ann Arbor, MI, USA; University of Michigan Medical School, Ann Arbor, MI, USA.
VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
J Psychiatr Res. 2024 Sep;177:31-38. doi: 10.1016/j.jpsychires.2024.07.003. Epub 2024 Jul 3.
Comorbid anxiety and depression predict a poorer prognosis than either disorder occurring alone. It is unclear whether self-reported anxiety symptom scores identify patients with depression in need of more intensive mental health services. This study evaluated how anxiety symptoms predicted treatment receipt and outcomes among patients with new depression diagnoses in the Veterans Health Administration (VHA). Electronic medical record data from 128,917 VHA patients (71.6% assessed for anxiety, n = 92,237) with new diagnoses of depression were analyzed to examine how Generalized Anxiety Disorder-7 (GAD-7) scores predicted psychotropic medication prescriptions, psychotherapy receipt, acute care service utilization, and follow-up depression symptoms. Patients who reported severe symptoms of anxiety were significantly more likely to receive adequate acute phase and continuation phase antidepressant treatment, daytime anxiolytics/sedatives, nighttime sedative/hypnotics, and endorse more severe depression symptoms and suicidal ideation at follow-up. Patients who reported severe symptoms of anxiety at baseline were less likely to initiate psychotherapy. The GAD-7 may help identify depressed patients who have more severe disease burden and require additional mental health services.
焦虑和抑郁共病预测预后比任何一种疾病单独发生都差。目前尚不清楚自我报告的焦虑症状评分是否能识别出需要更密集心理健康服务的抑郁患者。本研究评估了焦虑症状在退伍军人健康管理局 (VHA) 新诊断为抑郁症的患者中对治疗效果和结局的影响。分析了来自 128917 名 VHA 新诊断为抑郁症的患者(71.6%接受焦虑评估,n=92237)的电子病历数据,以检查广泛性焦虑障碍 7 项量表 (GAD-7) 评分如何预测精神药物处方、心理治疗、急性护理服务利用和随访抑郁症状。报告严重焦虑症状的患者更有可能接受足够的急性期和延续期抗抑郁治疗、日间抗焦虑/镇静剂、夜间镇静/催眠药,并且在随访时报告更严重的抑郁症状和自杀意念。基线时报告严重焦虑症状的患者更不可能开始心理治疗。GAD-7 可能有助于识别病情负担更重、需要更多心理健康服务的抑郁患者。