Unité de Recherche Clinique Intersectorielle en Psychiatrie à Vocation Régionale Pierre Deniker, Centre Hospitalier Henri Laborit, Poitiers, France; Centre de Recherches sur la Cognition et l'Apprentissage, CNRS 7295, Université de Poitiers, France.
Unité de Recherche Clinique Intersectorielle en Psychiatrie à Vocation Régionale Pierre Deniker, Centre Hospitalier Henri Laborit, Poitiers, France; Institut Pprime, UPR 3346, Université de Poitiers, France; Ansys France.
J Psychiatr Res. 2024 Sep;177:39-45. doi: 10.1016/j.jpsychires.2024.06.053. Epub 2024 Jun 29.
Obsessive-Compulsive Disorder (OCD) is characterized by intrusive thoughts and repetitive behaviors, with associated brain abnormalities in various regions. This study explores the correlation between neural biomarkers and the response to transcranial Direct Current Stimulation (tDCS) in OCD patients. Using structural MRI data from two tDCS trials involving 55 OCD patients and 28 controls, cortical thickness, and gray matter morphometry was analyzed. Findings revealed thicker precentral and paracentral areas in OCD patients, compared to control (p < 0.001). Correlations between cortical thickness and treatment response indicated a significant association between a thinner precentral area and reduced Yale-Brown Obsessive Compulsive Scale (YBOCS) scores (p = 0.02). While results highlight the complexity of treatment response predictors, this study sheds light on potential neural markers for tDCS response in OCD patients. Further investigations with larger datasets are warranted to better understand the underpinnings of these biomarkers and their implications for personalized treatment approaches.
强迫症（OCD）的特征是存在侵入性思维和重复性行为，伴有大脑各区域的异常。本研究旨在探讨强迫症患者的神经生物标志物与经颅直流电刺激（tDCS）反应之间的相关性。本研究使用了来自两项涉及 55 名强迫症患者和 28 名对照者的 tDCS 试验的结构 MRI 数据，分析了皮质厚度和灰质形态。研究结果显示，与对照组相比，强迫症患者的中央前回和中央旁回区域较厚（p < 0.001）。皮质厚度与治疗反应的相关性表明，中央前回变薄与耶鲁-布朗强迫症量表（YBOCS）评分降低之间存在显著关联（p = 0.02）。虽然研究结果突出了治疗反应预测因素的复杂性，但本研究为 tDCS 治疗强迫症患者的潜在神经标志物提供了新的见解。需要进一步开展基于更大数据集的研究，以更好地理解这些生物标志物的基础及其对个体化治疗方法的意义。
