非黑色素瘤皮肤癌的放射治疗：代表意大利放射治疗与临床肿瘤学会进行的一项意大利调查。

Radiation Therapy in Non-Melanoma Skin Cancers: An Italian Survey on Behalf of the Italian Association of Radiotherapy and Clinical Oncology.

作者信息

Pezzulla D, Pastore F, Fionda B, Cellini F, Di Franco R, Ciabattoni A, Corazzi F, Cossa S, Dominici L, Draghini L, Gherardi F, Lillo S, Longo S, Mazzarotto R, Navarria F, Piccolo F, Stefanelli A, Vicenzi L, Zamagni A, Maranzano E, Tagliaferri L

机构信息

Radiation Oncology Unit, Responsible Research Hospital, Italy.

Dipartimento di Diagnostica Per Immagini, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Radioterapia Oncologica ed Ematologia, Italy.

出版信息

Clin Oncol (R Coll Radiol). 2024 Dec;36(12):790-796. doi: 10.1016/j.clon.2024.06.006. Epub 2024 Jun 13.

DOI:10.1016/j.clon.2024.06.006

PMID:38971685

Abstract

AIMS

The National Palliative Care and Interventional Radiotherapy Study Groups of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) carried out a survey whose aim was to obtain a "snapshot" of the real-world practice of nonmelanoma skin cancer (NMSC) treatments in Italy.

MATERIALS AND METHODS

The survey was conducted on SurveyMonkey's online interface and was sent via e-mail to our society Radiation Oncologists.

RESULTS

Fifty-eight Italian radiation oncologists (ROs), representing 54 centers, answered the survey. Thirteen percent of the ROs declared they treat fewer than 10 NMSC lesions annually, 36% treat between 11 and 20, and 51% treat more than 20 lesions annually. Interventional radiotherapy (IRT) was offered by 25% of the ROs, and every case was reportedly discussed by a multidisciplinary team (71%). Electrons (74%), volumetric modulated arc therapy (V-MAT) (57%), three-dimensional conformal radiotherapy (3D-CRT) (43%), and IRT (26%) were the main treatment options. With external beam radiotherapy (EBRT), 46 and 53 different RT schedules were treated for curative and palliative intent, respectively; whereas for IRT, there were 21 and 7 for curative and palliative intent, respectively. The most popular EBRT curative options were 50-70.95/22-35 fractions (fx) and 50-70 Gy/16-20fx and for EBRT palliative settings, 30Gy/10fx, and 20-35Gy/5fx. For IRT, the most popular curative options were 32-50Gy/8-10fx and 30-54Gy/3-5fx, whereas 30Gy/6fz was the palliative option. Less than 10 re-RT cases were reported in one year in 42.5%, 11-20 cases in 42.5%, and >20 cases annually in 15%. Electrons (61%), VMAT (49%), and BRT (25%) were the most widely used approaches: 20-40Gy in 10fx and 20-25Gy in 5fx were the recommended fractionations.

CONCLUSION

The survey shows a variegated reality. A national registry with more detailed data could help in undercover its causes.

摘要

目的

意大利放射治疗与临床肿瘤学会（AIRO）的国家姑息治疗与介入放射治疗研究小组开展了一项调查，其目的是获取意大利非黑色素瘤皮肤癌（NMSC）治疗的真实世界实践的“快照”。

材料与方法

该调查在SurveyMonkey的在线界面上进行，并通过电子邮件发送给我们协会的放射肿瘤学家。

结果

代表54个中心的58名意大利放射肿瘤学家回答了该调查。13%的放射肿瘤学家宣称他们每年治疗少于10例NMSC病变，36%治疗11至20例，51%每年治疗超过20例病变。25%的放射肿瘤学家提供介入放射治疗（IRT），据报道每个病例都由多学科团队进行讨论（71%）。电子线放疗（74%）、容积调强弧形放疗（V-MAT）（57%）、三维适形放疗（3D-CRT）（43%）和IRT（26%）是主要的治疗选择。对于外照射放疗（EBRT），分别有46种和53种不同的放疗方案用于根治性和姑息性治疗目的；而对于IRT，根治性和姑息性治疗目的分别有21种和7种。最常用的EBRT根治性方案是50 - 70.95/22 - 35分次（fx）和5 /16 - 20fx，EBRT姑息性治疗方案是30Gy/10fx和20 - 35Gy/5fx。对于IRT，最常用的根治性方案是32 - 50Gy/8 - 10fx和30 - 54Gy/3 - 5fx，而姑息性方案是30Gy/6fz。42.5%的人报告一年内再程放疗病例少于10例，42.5%报告11至20例，15%报告每年超过20例。电子线放疗（61%）、VMAT（49%）和大分割放疗（BRT）（25%）是使用最广泛的方法：推荐的分割方式是10次分割照射20 - 40Gy和5次分割照射20 - 25Gy。