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高强度聚焦超声——进行肺动脉去神经支配的新选择。

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation.

作者信息

Xie Yonghui, Yao Taoyue, Zhu Xiaogang, Yang Fan, Fan Haoqin, Cao Shirui, Chen Huaiyang, Liao Manzhen, Xia Yuanxi, Liu Jinqiao, Xiao Zhenghui, Yang Zhou, Xiao Yunbin

机构信息

Academy of Pediatrics, University of South China, Changsha, 410007, China.

Department of Cardiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China.

出版信息

J Cardiovasc Transl Res. 2024 Dec;17(6):1353-1364. doi: 10.1007/s12265-024-10531-9. Epub 2024 Jul 6.

DOI:10.1007/s12265-024-10531-9
PMID:38971920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11635049/
Abstract

This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of 250W, 6 times for each rabbit, and an additional 6 rabbits served as controls. Then ATEPH was induced in both groups by intravenous infusion of autogeneic thrombus. Hemodynamics and ultrasonography parameters were measured by right heart catheter and echocardiography pre- and post-establishment of ATEPH models in both groups. Histological analysis and immunohistochemistry of tyrosine hydroxylase (TH) were also performed. After PADN procedures, 5 rabbits were successfully conducted PADN, of which ablation zone was also observed in right auricle or right lung in 4 rabbits. Ablation zone was detected only in right lung in 1 rabbit. Compared with control group, milder right heart hemodynamic changes were found in PADN group, accompanied by improved ultrasound parameters in PADN group. HIFU can acutly damage SNs around pulmonary artery successfully, which may be a new choice to conduct PADN. However, the accuracy of HIFU with PADN needs to be improved.

摘要

本研究旨在探讨高强度聚焦超声（HIFU）能否进行肺动脉去神经支配（PADN）。对6只血压正常的家兔肺动脉进行HIFU治疗，剂量为250W，每只家兔治疗6次，另外6只家兔作为对照。然后两组均通过静脉输注自体血栓诱导急性肺血栓栓塞症（ATEPH）。在两组建立ATEPH模型前后，通过右心导管和超声心动图测量血流动力学和超声参数。还进行了组织学分析和酪氨酸羟化酶（TH）免疫组织化学检测。在PADN操作后，5只家兔成功进行了PADN，其中4只家兔的右心耳或右肺也观察到消融区。1只家兔仅在右肺检测到消融区。与对照组相比，PADN组右心血流动力学变化较轻，同时PADN组超声参数有所改善。HIFU能够成功地急性损伤肺动脉周围的交感神经，这可能是进行PADN的一种新选择。然而，HIFU用于PADN的准确性有待提高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/031fa6982f36/12265_2024_10531_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/3d327dabd360/12265_2024_10531_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/44f29dd4ceca/12265_2024_10531_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/a775707a251c/12265_2024_10531_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/4e07b790b731/12265_2024_10531_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/80e1e7c50030/12265_2024_10531_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/e517252a443f/12265_2024_10531_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/0ecdcfc8c9c3/12265_2024_10531_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/031fa6982f36/12265_2024_10531_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/3d327dabd360/12265_2024_10531_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/44f29dd4ceca/12265_2024_10531_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/a775707a251c/12265_2024_10531_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/4e07b790b731/12265_2024_10531_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/80e1e7c50030/12265_2024_10531_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/e517252a443f/12265_2024_10531_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/0ecdcfc8c9c3/12265_2024_10531_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a7/11635049/031fa6982f36/12265_2024_10531_Fig8_HTML.jpg

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