Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China; Department of Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
J Nutr Biochem. 2024 Nov;133:109699. doi: 10.1016/j.jnutbio.2024.109699. Epub 2024 Jul 6.
Dietary strategies rich in fiber have been demonstrated to offer benefits to individuals afflicted with rheumatoid arthritis (RA). However, the specific mechanisms through which a high-fiber diet (HFD) mitigates RA's autoimmunity remain elusive. Herein, we investigate the influence of pectin- and inulin-rich HFD on collagen-induced arthritis (CIA). We establish that HFD significantly alleviates arthritis in CIA mice by regulating the Th17/Treg balance. The rectification of aberrant T cell differentiation by the HFD is linked to the modulation of gut microbiota, augmenting the abundance of butyrate in feces. Concurrently, adding butyrate to the drinking water mirrors the HFD's impact on ameliorating CIA, encompassing arthritis mitigation, regulating intestinal barrier integrity, and restoring the Th17/Treg equilibrium. Butyrate reshapes the metabolic profile of CD4 T cells in an AMPK-dependent manner. Our research underscores the importance of dietary interventions in rectifying gut microbiota for RA management and offers an explanation of how diet-derived microbial metabolites influence RA's immune-inflammatory-reaction.
富含纤维的饮食策略已被证明对类风湿关节炎（RA）患者有益。然而，高纤维饮食（HFD）减轻 RA 自身免疫的确切机制仍不清楚。本研究探讨了果胶和菊粉丰富的 HFD 对胶原诱导性关节炎（CIA）的影响。我们发现 HFD 通过调节 Th17/Treg 平衡显著减轻 CIA 小鼠的关节炎。HFD 对异常 T 细胞分化的纠正与肠道微生物群的调节有关，增加粪便中丁酸盐的丰度。同时，将丁酸盐添加到饮水中可以模拟 HFD 对 CIA 的改善作用，包括关节炎减轻、调节肠道屏障完整性和恢复 Th17/Treg 平衡。丁酸盐以 AMPK 依赖的方式重塑 CD4 T 细胞的代谢谱。我们的研究强调了饮食干预在纠正肠道微生物群以管理 RA 方面的重要性，并解释了饮食衍生的微生物代谢产物如何影响 RA 的免疫炎症反应。
