Pien F D, Shrum S, Swenson J M, Hill B C, Thornsberry C, Farmer J J
J Clin Microbiol. 1985 Aug;22(2):283-5. doi: 10.1128/jcm.22.2.283-285.1985.
In this report we present clinical descriptions of 12 Hawaiian patients from whom Escherichia vulneris or E. hermannii strains were isolated. All but two patients had soft-tissue infections with multiple bacteria, particularly Staphylococcus aureus. The other two had purulent conjunctivitis associated with S. aureus and infected malignant peritonitis with multiple organisms, respectively. In none of the cases were the Escherichia spp. found in abundant quantities or considered pathogenic. In preliminary animal pathogenicity studies, 12 strains each of E. vulneris and E. hermannii failed to cause serious symptoms in 4-week-old mice when 10(7) cells were injected intraperitoneally. When 10(6) cells were used, none of these bacterial strains injected into mouse soft tissue was capable of producing persistent wound infections. Susceptibility studies of 40 strains of these bacteria to 20 different antimicrobial agents showed that they were susceptible to third-generation cephalosporins as well as to most other cephalosporins, aminoglycosides, trimethoprim, and sulfamethoxazole-trimethoprim; these strains were only marginally susceptible or resistant to penicillin, tetracycline, chloramphenicol, and nitrofurantoin.
在本报告中，我们呈现了12例分离出脆弱埃希菌或赫尔曼埃希菌菌株的夏威夷患者的临床描述。除两名患者外，其余患者均患有多种细菌引起的软组织感染，尤其是金黄色葡萄球菌。另外两名患者分别患有与金黄色葡萄球菌相关的脓性结膜炎和多种微生物感染的恶性腹膜炎。在所有病例中，均未发现大量的埃希菌属细菌，也未将其视为病原体。在初步的动物致病性研究中，当向4周龄小鼠腹腔注射10⁷个脆弱埃希菌和赫尔曼埃希菌菌株时，均未引起严重症状。当使用10⁶个细菌时，注射到小鼠软组织中的这些菌株均不能产生持续性伤口感染。对40株这些细菌对20种不同抗菌药物的敏感性研究表明，它们对第三代头孢菌素以及大多数其他头孢菌素、氨基糖苷类、甲氧苄啶和磺胺甲恶唑-甲氧苄啶敏感；这些菌株对青霉素、四环素、氯霉素和呋喃妥因仅轻度敏感或耐药。
