Shen Yingzheng, Zhuang Xiayan, Li Chuangwei, Yao Danmian
Department of Otolaryngology&Head and Neck Surgery,Shantou Central Hospital,Shantou,515000,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Jul;38(7):641-645;650. doi: 10.13201/j.issn.2096-7993.2024.07.016.
To investigate the distribution of common allergens and indoor factors influencing the severity of allergic rhinitis in patients from the Chaoshan region. Patients diagnosed with allergic rhinitis from Shantou, Jieyang, and Chaozhou were selected for serum allergen-specific IgE testing. A questionnaire survey was conducted to analyze the distribution of allergens and indoor factors affecting the severity of the disease. A total of 1 800 questionnaires were collected, with 1 646 valid responses, resulting in an effective response rate of 91.4%. Among the 1 646 included patients with allergic rhinitis, there were 1 285 children(≤14 years) ,361 adolescents and adults(>14 years);of which 999 were males and 647 were females. The top three allergens with the highest positive rates were house dust mites(=1 457, 88.5%), milk(=569, 34.6%), and crab(=360, 21.9%). The proportions of allergen sensitization to house dust mites, house dust, dog dander, egg white, milk, fish, crab, shrimp, and beef showed statistically significant differences between children and adolescents and adults(<0.01). There were also statistically significant differences in crab and shrimp sensitization between males and females(<0.01). Multivariate analysis revealed that active/passive smoking, religious rituals, air conditioning usage, pet ownership, air purifier usage, and bedding drying were indoor factors influencing the severity of allergic rhinitis. Among them, active/passive smoking, religious rituals, air conditioning usage, and pet ownership were risk factors for exacerbating the disease, while air purifier usage and bedding drying were protective factors. House dust mites are the most common allergen in patients with allergic rhinitis in the Chaoshan region. Active/passive smoking, religious rituals, air conditioning usage, and pet ownership can worsen the condition, while air purifier usage and bedding drying can help control the disease. The results of this study can provide clinical reference.
调查潮汕地区变应性鼻炎患者常见变应原的分布及影响病情严重程度的室内因素。选取来自汕头、揭阳和潮州诊断为变应性鼻炎的患者进行血清变应原特异性IgE检测。开展问卷调查以分析变应原分布及影响病情严重程度的室内因素。共收集问卷1800份,有效问卷1646份,有效应答率为91.4%。纳入的1646例变应性鼻炎患者中,儿童(≤14岁)1285例,青少年及成人(>14岁)361例;其中男性999例,女性647例。阳性率最高的前三种变应原为屋尘螨(=1457,88.5%)、牛奶(=569,34.6%)和蟹(=360,21.9%)。儿童与青少年及成人对屋尘螨、屋尘、狗毛、蛋清、牛奶、鱼、蟹、虾和牛肉的变应原致敏比例差异有统计学意义(<0.01)。男性与女性对蟹和虾的致敏差异也有统计学意义(<0.01)。多因素分析显示,主动/被动吸烟、宗教仪式、使用空调、饲养宠物、使用空气净化器及晾晒被褥是影响变应性鼻炎病情严重程度的室内因素。其中,主动/被动吸烟、宗教仪式、使用空调及饲养宠物是疾病加重的危险因素,而使用空气净化器及晾晒被褥是保护因素。屋尘螨是潮汕地区变应性鼻炎患者最常见的变应原。主动/被动吸烟、宗教仪式、使用空调及饲养宠物会使病情加重,而使用空气净化器及晾晒被褥有助于控制病情。本研究结果可为临床提供参考。