Wang Jiaqi, Li Zhoufang, Zhao Qi
Cancer Centre, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
Core Research Facilities, Southern University of Science and Technology, Shenzhen 518055, China.
J Leukoc Biol. 2025 Feb 13;117(2). doi: 10.1093/jleuko/qiae141.
Receptor tyrosine kinase-like orphan receptor (ROR), consisting of ROR1 and ROR2, is a conserved family of receptor tyrosine kinase superfamily that plays crucial roles during embryonic development with limited expression in adult normal tissues. However, it is overexpressed in a range of hematological malignancies and solid tumors and functions in cellular processes including cell survival, polarity, and migration, serving as a potential target in cancer immunotherapy. This review summarizes the expression and structure of ROR in developmental morphogenesis and its function in cancers associated with Wnt5a signaling and highlights the cancer immunotherapy strategies targeting ROR.
受体酪氨酸激酶样孤儿受体（ROR）由ROR1和ROR2组成，是受体酪氨酸激酶超家族的一个保守家族，在胚胎发育过程中起关键作用，在成人正常组织中表达有限。然而，它在一系列血液系统恶性肿瘤和实体瘤中过度表达，并在包括细胞存活、极性和迁移在内的细胞过程中发挥作用，是癌症免疫治疗的潜在靶点。本文综述了ROR在发育形态发生中的表达和结构及其在与Wnt5a信号相关的癌症中的功能，并重点介绍了针对ROR的癌症免疫治疗策略。
