Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Division of Multidisciplinary Management of Rheumatic Diseases, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Int J Rheum Dis. 2024 Jul;27(7):e15254. doi: 10.1111/1756-185X.15254.
To evaluate whether seasonal changes influence fluctuations in serum Krebs von den Lungen-6 (KL-6) levels in systemic sclerosis-related interstitial lung disease (SSc-ILD).
Summer was defined as the period between July and September, and winter as between December and February. The study was conducted between 2015 and 2016, with a focus on these two seasons. A diagnosis of ILD and ILD progression overtime were evaluated using chest computed tomography. Among patients with SSc-ILD, those with data on serum KL-6 and lactate dehydrogenase (LDH) levels in the 2015 winter, 2015 summer, and 2016 winter seasons were included. Patients with comorbidities that could affect serum KL-6 levels were excluded.
Of 60 patients with SSc-ILD, 52 (86.7%) had stable ILD, 5 (8.3%) had worsened ILD, and 3 (5.0%) had improved ILD. Serum KL-6 levels were significantly higher during the winter than those during the summer (2015 winter vs. 2015 summer: 649 U/mL vs. 585 U/mL, p < .0001; 2016 winter vs. 2015 summer: 690 U/mL vs. 585 U/mL, p < .0001). No significant differences were observed between the winters of 2015 and 2016 (649 U/mL vs. 690 U/mL, p = .78). However, serum LDH levels did not exhibit seasonal fluctuations (2015 winter vs. 2015 summer: 203 U/L vs. 199 U/L, p = .3; 2016 winter vs. 2015 summer: 201 U/L vs. 199 U/L, p = .6; 2015 winter vs. 2016 winter: 203 U/L vs. 201 U/L, p = .24).
Seasonal fluctuations in serum KL-6 levels were observed in patients with SSc-ILD.
评估季节性变化是否会影响系统性硬皮病相关间质性肺疾病（SSc-ILD）患者血清 Krebs von den Lungen-6（KL-6）水平的波动。
夏季定义为 7 月至 9 月之间，冬季为 12 月至 2 月之间。该研究于 2015 年至 2016 年进行，重点关注这两个季节。通过胸部计算机断层扫描评估ILD 和ILD 随时间的进展。在 SSc-ILD 患者中，纳入了 2015 年冬季、2015 年夏季和 2016 年冬季血清 KL-6 和乳酸脱氢酶（LDH）水平数据的患者。排除了患有可能影响血清 KL-6 水平的合并症的患者。
在 60 例 SSc-ILD 患者中，52 例（86.7%）ILD 稳定，5 例（8.3%）ILD 恶化，3 例（5.0%）ILD 改善。与夏季相比，冬季血清 KL-6 水平明显升高（2015 年冬季与 2015 年夏季：649 U/mL 比 585 U/mL，p<0.0001；2016 年冬季与 2015 年夏季：690 U/mL 比 585 U/mL，p<0.0001）。2015 年和 2016 年冬季之间没有显著差异（649 U/mL 比 690 U/mL，p=0.78）。然而，血清 LDH 水平没有季节性波动（2015 年冬季与 2015 年夏季：203 U/L 比 199 U/L，p=0.3；2016 年冬季与 2015 年夏季：201 U/L 比 199 U/L，p=0.6；2015 年冬季与 2016 年冬季：203 U/L 比 201 U/L，p=0.24）。
在 SSc-ILD 患者中观察到血清 KL-6 水平的季节性波动。
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