Pozniak P C
J Am Diet Assoc. 1985 Sep;85(9):1127-33.
This article reviews 18 years of research on the carcinogenic effects of both caffeine and coffee. Caffeine, the most widely consumed drug in the United States, has been the subject of numerous studies. It has been found to both increase and decrease malignant cell development, on the cellular and subcellular level, depending on the carcinogen it is used with, the type of host cell, and the stage of cell cycle in which it is introduced. No causal relationship has been established between coffee intake and lower urinary tract cancer, pancreatic cancer, breast cancer or fibrocystic breast disease, ovarian cancer, or large bowel cancer.
本文回顾了18年来关于咖啡因和咖啡致癌作用的研究。咖啡因是美国消费最为广泛的药物，一直是众多研究的对象。在细胞和亚细胞水平上，根据与之共同作用的致癌物、宿主细胞类型以及引入时细胞周期的阶段，已发现咖啡因对恶性细胞的发展既有促进作用又有抑制作用。咖啡摄入量与下尿路癌症、胰腺癌、乳腺癌或乳腺纤维囊性疾病、卵巢癌或大肠癌之间尚未确立因果关系。
