Garachetla Hari K, Takagi Kiyoshi, Takagi Ryosuke, Kato Yoko
Department of Neurosurgery, Paras Hospitals, New Delhi, India.
Department of Neurosurgery, Fujita Health University, Bantane Hospital, Nagoya, Japan.
Asian J Neurosurg. 2024 Jun 5;19(2):295-300. doi: 10.1055/s-0044-1787053. eCollection 2024 Jun.
Vascular dementia (VaD) is the second most common cause of dementia after Alzheimer's disease. While new therapeutic modalities have been available for Alzheimer's disease, there is currently no effective treatment for VaD. We encountered two cases with VaD who recovered their cognitive function to normal levels after ventriculoatrial shunt (VA shunt). Both cases complained cognitive impairment shortly after cerebral infarctions. Their brain images showed ventricular dilatation without the findings of disproportionately enlarged subarachnoid space hydrocephalus, which is regarded as characteristic for idiopathic normal pressure hydrocephalus (iNPH). Both cases were initially diagnosed as VaD by board neurosurgeons. However, since they showed positive response to lumbar tap test, VA shunts were performed. Both cases recovered their cognitive function to normal level. Their excellent cognitive outcomes after VA shunts indicate that many iNPH patients with lacunar infarcts may possibly be misdiagnosed as VaD.
血管性痴呆(VaD)是仅次于阿尔茨海默病的第二常见痴呆病因。虽然针对阿尔茨海默病已有新的治疗方法,但目前VaD尚无有效治疗手段。我们遇到两例VaD患者,在进行脑室心房分流术(VA分流术)后认知功能恢复到正常水平。两例患者均在脑梗死后不久出现认知障碍。他们的脑部影像显示脑室扩张,未发现蛛网膜下腔不成比例扩大性脑积水的表现,而这被视为特发性正常压力脑积水(iNPH)的特征。两例患者最初均由神经外科专家诊断为VaD。然而,由于他们对腰椎穿刺试验呈阳性反应,因此进行了VA分流术。两例患者的认知功能均恢复到正常水平。他们在VA分流术后出色的认知结果表明,许多伴有腔隙性梗死的iNPH患者可能被误诊为VaD。