Wongsirisuwan Methee
Department of Neurosurgery, Rajvithi Hospital, Bangkok, Thailand.
Asian J Neurosurg. 2024 Jun 7;19(2):290-294. doi: 10.1055/s-0044-1787673. eCollection 2024 Jun.
BioGlue is touted as a safe and effective sealant for various surgical procedures. This article describes five cases of delayed wound healing associated with the use of BioGlue after craniectomies. Five patients of different genders and ages who had undergone craniectomy with BioGlue were presented to our medical center with wound dehiscence and purulent discharge. The first attempt to solve this problem by incision and drainage was unsuccessful. The removal of BioGlue is necessary to eliminate these problems. The presence of wound dehiscence and aseptic cystic contents may indicate a chronic inflammatory process following the application of BioGlue. This problem usually occurs within a few months after wound closure. For rapid intervention, it is recommended to perform an incision and drainage and remove the BioGlue. The main risk factor is directly applying BioGlue to the skin, subcutaneous tissue, or titanium material. Neurosurgeons should exercise caution and be aware of a possible delayed chronic inflammatory process in surgical wounds associated with the use of BioGlue as a sealant, especially when the product is used without cranial coverage or in cases where it comes into direct contact with subcutaneous tissue or titanium material. To resolve this issue quickly, BioGlue should be completely removed at the first attempt at incision and drainage.
BioGlue被吹捧为适用于各种外科手术的一种安全有效的密封剂。本文描述了5例颅骨切除术后使用BioGlue导致伤口愈合延迟的病例。 5例不同性别和年龄的患者在颅骨切除术中使用了BioGlue，因伤口裂开和脓性分泌物被送至我们的医疗中心。首次通过切开引流解决该问题的尝试未成功。必须去除BioGlue以消除这些问题。 伤口裂开和无菌性囊内容物的存在可能表明使用BioGlue后出现了慢性炎症过程。这个问题通常在伤口闭合后的几个月内出现。为了迅速干预，建议进行切开引流并去除BioGlue。主要危险因素是将BioGlue直接应用于皮肤、皮下组织或钛材料。 神经外科医生应谨慎行事，并意识到在使用BioGlue作为密封剂的手术伤口中可能会出现延迟的慢性炎症过程，尤其是在该产品未覆盖颅骨使用或与皮下组织或钛材料直接接触的情况下。为了迅速解决这个问题，在首次切开引流时应彻底清除BioGlue。
