估算慢性肾脏病患者继发性甲状旁腺功能亢进症的全球患病率。
Estimating the global prevalence of secondary hyperparathyroidism in patients with chronic kidney disease.
机构信息
Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Laboratory of Thyroid and Parathyroid Diseases, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Front Endocrinol (Lausanne). 2024 Jun 21;15:1400891. doi: 10.3389/fendo.2024.1400891. eCollection 2024.
BACKGROUND
Chronic kidney disease (CKD)-related secondary hyperparathyroidism (SHPT) is associated with higher morbidity and death. The goal of this study was to mine the SHPT data already available to do a meta-analysis on the global prevalence of SHPT caused by CKD.
METHODS
Embase, Medline, Web of Science, Cochrane Central Databases, and Google Scholar were searched to identify studies on the prevalence of SHPT due to CKD from inception to November 2023. Pooled prevalence was calculated using the DerSimonian-Laird random effects model with a logit transformation.
RESULTS
Twenty-one eligible studies involving 110977 patients were included. Our results revealed that the estimated global prevalence of SHPT due to CKD was 49.5% (95% CI 30.20-68.18), regardless of the diagnostic criteria. For subgroup analysis, Southern Asia (84.36%, 95% CI 79.35-88.34) had a significantly higher SHPT prevalence than other geographic regions. SHPT due to CKD was most prevalent in China (85.14%, 95% CI 81.74-88.00).
CONCLUSIONS
SHPT due to CKD is highly prevalent. This necessitates awareness and therapeutic approaches from primary care physicians, medical professionals, and health strategy authorities.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO, identifier CRD42024514007.
背景
慢性肾脏病（CKD）相关的继发性甲状旁腺功能亢进症（SHPT）与更高的发病率和死亡率相关。本研究的目的是挖掘已经可用的 SHPT 数据，对 CKD 引起的 SHPT 的全球患病率进行荟萃分析。
方法
从建库至 2023 年 11 月，我们在 Embase、Medline、Web of Science、Cochrane 中央数据库和 Google Scholar 上搜索了关于 CKD 引起的 SHPT 患病率的研究。使用德西曼-莱尔德随机效应模型和对数转换计算汇总患病率。
结果
共纳入 21 项符合条件的研究，涉及 110977 例患者。我们的结果显示，CKD 引起的 SHPT 的全球估计患病率为 49.5%（95%CI 30.20-68.18），无论采用何种诊断标准。对于亚组分析，南亚（84.36%，95%CI 79.35-88.34）的 SHPT 患病率明显高于其他地理区域。中国（85.14%，95%CI 81.74-88.00）CKD 引起的 SHPT 患病率最高。
结论
CKD 引起的 SHPT 患病率很高。这需要初级保健医生、医疗专业人员和卫生策略当局提高认识并采取治疗措施。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO，标识符 CRD42024514007。
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