Mokline A, Zarrouk S, Jemi I, Fraj H, Gasri B, Ben Saad M, Thabet L, Messadi A A
Ann Burns Fire Disasters. 2024 Jun 30;37(2):106-111. eCollection 2024 Jun.
Resistance to carpabenems in burns is rapidly spreading in many countries. Therefore identification of carbapenemase pathogen carriers is imperative in order to establish adequate infection control precautions and stop outbreaks of these multidrug-resistant bacteria. The aim of our study was to evaluate the distribution of carbapenemase producers in burn patients admitted to a burn center in Tunisia over 9 months. PCR for carbapenemase portage was performed in all patients within 48 hours of admission. Seventeen patients carried a single carbapenemase, 11 carried two, and 25 carried three. The enzymes detected were VIM (n=41), NDM (n=41) and OXA48 (n=32). Enzyme mapping revealed two main areas of carriage in central western Tunisia: Kairouan (NDM/OXA48) and Kasserine (NDM/VIM). Predictive factors for carriage of carbapenemase were: prior antibiotic therapy (n=24); mechanical ventilation (n=30); vascular catheterization (n=31) and a previous stay in intensive care (n=11).
在许多国家，烧伤患者对碳青霉烯类药物的耐药性正在迅速蔓延。因此，识别碳青霉烯酶病原体携带者对于建立适当的感染控制预防措施并阻止这些多重耐药菌的爆发至关重要。我们研究的目的是评估突尼斯一家烧伤中心9个月内入院的烧伤患者中碳青霉烯酶产生菌的分布情况。在所有患者入院48小时内进行碳青霉烯酶携带情况的PCR检测。17例患者携带一种碳青霉烯酶，11例携带两种，25例携带三种。检测到的酶为VIM（n = 41）、NDM（n = 41）和OXA48（n = 32）。酶谱分析显示突尼斯中西部有两个主要携带区域：凯鲁万（NDM/OXA48）和凯塞林（NDM/VIM）。碳青霉烯酶携带的预测因素为：先前的抗生素治疗（n = 24）；机械通气（n = 30）；血管插管（n = 31）以及先前在重症监护病房住院（n = 11）。
