Dortet Laurent, Cuzon Gaëlle, Ponties Valérie, Nordmann Patrice
Associated National Reference Center for Antibiotic Resistance, Le Kremlin-Bicêtre, France.
Faculty of Medecine, South-Paris University, Le Kremlin-Bicêtre, France.
Euro Surveill. 2017 Feb 9;22(6). doi: 10.2807/1560-7917.ES.2017.22.6.30461.
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased susceptibility to carbapenems received at the NRC rapidly increased (more than twofold in two years) with a growing proportion of carbapenemase producers (23.1% in 2012 vs 28.6% in 2013 vs 36.2% in 2014). Between 2012 and 2014, the main carbapenemase type was OXA-48, with an increase in OXA-48 variants (mostly OXA-181) and NDM producers, whereas the number KPC producers decreased. We identified a potential spread of OXA-181 producers in the tropical region of Africa. Finally, OXA-48 and OXA-48-related enzymes remained the predominant carbapenemases in France. The number of carbapenemase-producing Escherischia coli isolates was multiplied by fivefold between 2012 and 2014, suggesting a possible dissemination in the community.
2014年，法国国家抗生素耐药性联合参考中心（NRC）共收到2976株对碳青霉烯类药物敏感性降低的肠杆菌科分离株，对其碳青霉烯类药物的分子耐药机制进行了鉴定，并与2012年和2013年获得的结果进行了比较。NRC收到的对碳青霉烯类药物敏感性降低的肠杆菌分离株总数迅速增加（两年内增加了两倍多），产碳青霉烯酶的比例不断上升（2012年为23.1%，2013年为28.6%，2014年为36.2%）。2012年至2014年间，主要的碳青霉烯酶类型为OXA-48，OXA-48变体（主要是OXA-181）和产NDM酶菌株数量增加，而产KPC酶菌株数量减少。我们发现OXA-181产酶菌株在非洲热带地区有潜在传播。最后，OXA-48和与OXA-48相关的酶仍然是法国主要的碳青霉烯酶。2012年至2014年间，产碳青霉烯酶的大肠杆菌分离株数量增加了五倍，表明可能在社区中传播。
