Orihashi Ryuzo, Imamura Yoshiomi, Mizoguchi Yoshito
Institute of Nursing, Faculty of Medicine, Saga University, Japan.
Department of Psychiatry, Faculty of Medicine, Saga University, Japan.
J Rural Med. 2024 Jul;19(3):186-191. doi: 10.2185/jrm.2024-018. Epub 2024 Jul 1.
Identifying the peripheral biomarkers related to the prevention or modification of unhealthy mental conditions in older adults is extremely beneficial. This study aimed to evaluate the serum levels of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble form of an innate immune receptor expressed on microglia, in older adults living in a rural community, and their association with cognitive function. This survey was conducted between November 2016 and September 2017 in Kurokawa-cho, Imari, Saga Prefecture, Japan, among people aged ≥65 years. Blood samples were collected from the participants for serum sTREM2 level analysis using a peptide enzyme immunoassay. The participants underwent cognitive function assessments, including the Mini-Mental State Examination, Clinical Dementia Rating, and Frontal Assessment Battery. Therefore, we examined the association between serum sTREM2 levels and cognitive function. Of the 95 participants, 25 were men and 70 were women with a mean age 78.24 ± 3.85 years and 77.96 ± 5.52 years, respectively. Serum sTREM2 levels were negatively associated with Frontal Assessment Battery scores, even after adjusting for age, sex, years of education, and serum high-sensitivity C-reactive protein levels. Serum sTREM2 levels may be associated with frontal lobe function in adults aged ≥65 years.
识别与预防或改善老年人不健康心理状况相关的外周生物标志物极为有益。本研究旨在评估日本佐贺县伊万里市黑川町65岁及以上老年人中髓系细胞触发受体2（sTREM2，一种在小胶质细胞上表达的先天免疫受体的可溶性形式）的血清水平，及其与认知功能的关联。这项调查于2016年11月至2017年9月在日本佐贺县伊万里市黑川町进行，对象为年龄≥65岁的人群。采集参与者的血样，使用肽酶免疫分析法分析血清sTREM2水平。参与者接受了认知功能评估，包括简易精神状态检查表、临床痴呆评定量表和额叶评估量表。因此，我们研究了血清sTREM2水平与认知功能之间的关联。95名参与者中，25名男性，70名女性，平均年龄分别为78.24±3.85岁和77.96±5.52岁。即使在调整年龄、性别、受教育年限和血清高敏C反应蛋白水平后，血清sTREM2水平仍与额叶评估量表得分呈负相关。血清sTREM2水平可能与65岁及以上成年人的额叶功能有关。
