Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Acta Histochem. 2024 Oct;126(5-7):152174. doi: 10.1016/j.acthis.2024.152174. Epub 2024 Jul 7.
Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM.
脉络膜黑色素瘤 (CM) 是一种高度转移性眼部肿瘤，表现出缺氧诱导的血管生成所促进的血管生成拟态 (VM)。本研究通过调节 HIF-1α/VEGF/PDGF 通路，探讨了抗疟药物青蒿琥酯 (ART) 对 CM VM 的抑制作用。免疫组化 (IHC) 证实 CM 中存在 VM，表现为 VEGF 和 PDGF 表达升高。缺氧促进 CM 增殖，上调 HIF-1α、VEGF 和 PDGF。VEGF 和 PDGF 增强了 CM 的迁移、侵袭和 VM，其中 HIF-1α 发挥了关键作用。ART 通过抑制 HIF-1α/VEGF/PDGF 通路减轻 VM 形成，突显其在 CM 中作为抗肿瘤药物的潜力。
