Department of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology & Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
Department of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology & Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
Int Immunopharmacol. 2024 Sep 10;138:112252. doi: 10.1016/j.intimp.2024.112252. Epub 2024 Jul 7.
T cell induced cellular immunity is considered to be extremely important for the control of tuberculosis (TB). T cell receptor (TCR), the key component responsible for the specificity and clustering of T cells, holds the potential to advance our understanding of T cell immunity against TB infection. This review systematically expounded the study progressions made in the field of TB-relevant TCRs based on single cell sequencing together with GLIPH2 technology and initiated a comparison of the T cell distribution between peripheral blood and infected organs. We divided clonal expanded T cell clones into recirculation subsets and local subsets to summarize their distinctions in clonal abundance, TCR sequences and antigenic specificity. Notably, local expansion appears to drive the primary variances in T cell subsets between these two contexts, indicating the necessity for further exploration into the functions and specificity of local subsets.
T 细胞诱导的细胞免疫被认为对控制结核病（TB）至关重要。T 细胞受体（TCR）是负责 T 细胞特异性和聚集的关键组成部分，有可能加深我们对针对 TB 感染的 T 细胞免疫的理解。本综述系统地阐述了基于单细胞测序与 GLIPH2 技术的 TB 相关 TCR 领域的研究进展，并比较了外周血和感染器官中 T 细胞的分布。我们将克隆扩增的 T 细胞克隆分为再循环亚群和局部亚群，以总结它们在克隆丰度、TCR 序列和抗原特异性方面的差异。值得注意的是，局部扩增似乎驱动了这两个环境中 T 细胞亚群的主要差异，表明需要进一步探索局部亚群的功能和特异性。
