Department of Pharmacy, Tongde Hospital of ZheJiang Province, Hangzhou, Zhejiang, People's Republic of China.
Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, People's Republic of China.
BMC Psychiatry. 2024 Jul 8;24(1):491. doi: 10.1186/s12888-024-05668-5.
Rash is one of common adverse drug reaction and which have been reported in typical and atypical antipsychotics. Reports of lurasidone induced skin reactions are sparse. In this study, we report a case of rash caused by lurasidone.
A 63-year-old man with bipolar disorder (BD) who is treated by lurasidone. However, the patient presents a rash all over after lurasidone dose increasing from 40 mg/day to 60 mg/day. With the diagnosis of drug induced rash, lurasidone was discontinued, and the rash complete disappears within 2 weeks. In addition, all case reports about antipsychotics associated rash were reviewed by searching English and Chinese database including Pubmed, Embase, Cochrane Library, CNKI and Wanfang database. A total of 139 articles contained 172 patients were included in our study. The literature review and our case suggest that the cutaneous adverse events caused by antipsychotic drugs should not be ignored, particularly for the patient who was first use or at dose increasing of antipsychotic.
In conclusion, we report a case of lurasidone related rash and review rash caused by antipsychotics. Psychiatrists should be alert to the possibility of the rash caused by antipsychotics, especially the patient was first use of antipsychotics or the antipsychotic dose was increasing.
皮疹是一种常见的药物不良反应，在典型和非典型抗精神病药物中均有报道。关于鲁拉西酮引起皮肤反应的报告很少。在本研究中，我们报告了一例由鲁拉西酮引起的皮疹病例。
一名 63 岁男性，患有双相情感障碍（BD），接受鲁拉西酮治疗。然而，在鲁拉西酮剂量从 40mg/天增加到 60mg/天后，患者全身出现皮疹。诊断为药物引起的皮疹后，停用了鲁拉西酮，皮疹在 2 周内完全消失。此外，通过检索 Pubmed、Embase、Cochrane 图书馆、CNKI 和万方数据库，对所有关于抗精神病药相关皮疹的病例报告进行了综述，共纳入 139 篇文章，包含 172 例患者。文献回顾和我们的病例表明，抗精神病药物引起的皮肤不良反应不容忽视，特别是对于首次使用或增加抗精神病药物剂量的患者。
总之，我们报告了一例鲁拉西酮相关皮疹病例，并对抗精神病药引起的皮疹进行了综述。精神科医生应警惕抗精神病药引起皮疹的可能性，尤其是患者首次使用抗精神病药或增加抗精神病药剂量时。
