Department of Pathology, Harbin Medical University Cancer Hospital, Harbin City, 150081, People's Republic of China.
Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin City, 150081, People's Republic of China.
BMC Public Health. 2024 Jul 8;24(1):1819. doi: 10.1186/s12889-024-19313-z.
This prospective cohort study aimed to investigate the relationship between sleep duration and cancer incidence among 9996 participants over a median follow-up period of 9 years.
Participants without cancer at baseline were followed for over 88,790 person-years. The incidence of cancer and sleep duration was self-reported. The relationship between sleep duration and cancer incidence was analyzed using Cox proportional hazards models adjusted for various confounding factors, including age, gender, lifestyle factors, and comorbidities.
During the follow-up, 325 participants were diagnosed with incident cancer, resulting in an incidence rate of 20.49 per 1000 person-years. After adjusting for confounders, a total sleep duration of less than 6 h was significantly associated with an increased risk of cancer (HR: 1.27; 95% CI: 1.01-1.61). This association was particularly strong for cancers in the digestive and respiratory systems (HR: 1.41; 95% CI: 1.03-1.93). Longer sleep durations (> 9 h) showed a potential increase in cancer risk, but results were not consistently significant. Age-stratified analyses revealed a similar significant increase in cancer incidence among individuals aged 60 years or younger with less than 6 h of sleep per day, showing a 35% increase in overall cancer risk and an 83% increase in digestive and respiratory system cancer. No significant association was found between nocturnal sleep durations or daytime naps and cancer incidence. However, a significant interaction was observed between daytime naps longer than 30 min and cancer incidence in women (p = 0.041).
We observed that short sleep duration may increase the risk of cancer, particularly cancers in the digestive and respiratory systems. Additionally, while longer sleep durations might also increase cancer risk, this finding requires validation with larger sample sizes.
本前瞻性队列研究旨在调查 9996 名参与者在中位随访 9 年期间的睡眠时长与癌症发病率之间的关系。
无基线癌症的参与者随访超过 88790 人年。癌症和睡眠时长的发病率通过自我报告进行评估。使用 Cox 比例风险模型分析睡眠时长与癌症发病率之间的关系，调整了包括年龄、性别、生活方式因素和合并症等多种混杂因素。
在随访期间，325 名参与者被诊断为新发癌症，发病率为 20.49/1000 人年。在调整混杂因素后，总睡眠时间少于 6 小时与癌症风险增加显著相关（HR：1.27；95%CI：1.01-1.61）。这种关联在消化系统和呼吸系统癌症中尤为明显（HR：1.41；95%CI：1.03-1.93）。睡眠时间较长（>9 小时）可能会增加癌症风险，但结果并不始终显著。年龄分层分析显示，每天睡眠不足 6 小时且年龄在 60 岁或以下的个体中，癌症发病率也显著增加，总体癌症风险增加 35%，消化系统和呼吸系统癌症风险增加 83%。夜间睡眠时间或日间小睡与癌症发病率之间没有显著关联。然而，在女性中观察到日间小睡超过 30 分钟与癌症发病率之间存在显著的交互作用（p=0.041）。
我们观察到，短睡眠时间可能会增加癌症风险，尤其是消化系统和呼吸系统癌症。此外，虽然较长的睡眠时间也可能增加癌症风险，但这一发现需要更大的样本量进行验证。
