Cardiac Arrhythmia Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei Li Shi Rd, Xicheng District, Beijing, 100037, China.
BMC Public Health. 2024 Jul 8;24(1):1817. doi: 10.1186/s12889-024-19326-8.
The combined association of physical activity (PA) and alcohol use (AU) with long-term mortality is yet to be investigated.
For the current study, 12,621 participants aged ≥ 20 years were enrolled from the National Health and Nutrition Examination Survey (1999-2004). The study endpoint was all-cause mortality. Cox proportional hazards regression models were used to examine the combined effect of PA and AU on long-term mortality.
The study population was divided into young (< 60 years, N = 8,258) and old (≥ 60 years, N = 4,363) groups. The median follow-up time was 203 months. In both young and old group, sedentary lifestyle combined with even minimal AU were associated with elevated risk of death (all P < 0.05). In young group, the integration of high volume AU with any degree of PA, including sedentary PA (HR = 2.35, 95% CI 1.24-4.44, P = 0.009), low PA (HR = 1.64, 95% CI 1.01-2.68, P = 0.047), and moderate-to-vigorous PA (HR = 1.99, 95% CI 1.03-3.84, P = 0.041), was associated with an increased risk of mortality. This relationship persisted as significant after adjusting for potential confounders (all P < 0.05). In old group, combining moderate-to-vigorous PA and low volume AU (HR = 0.59, 95% CI 0.37-0.94, P = 0.027) was associated with a reduction in mortality. After adjustment, the combination of moderate-to-vigorous PA and low volume AU was independently associated with favorable prognostic outcomes (all P < 0.05).
In both age groups, combining sedentary lifestyle with even minimal AU was a risk factor for death. In young group, combining any level of PA with high volume AU was associated with increased mortality. In old group, combining moderate-to-vigorous PA with low volume AU was related to reduced mortality.
体力活动（PA）和饮酒（AU）的联合与长期死亡率的关联尚未被研究。
在本研究中，共纳入 12621 名年龄≥20 岁的参与者，他们来自国家健康和营养调查（1999-2004 年）。研究终点是全因死亡率。使用 Cox 比例风险回归模型来检验 PA 和 AU 的联合作用对长期死亡率的影响。
研究人群分为年轻（<60 岁，N=8258）和年老（≥60 岁，N=4363）两组。中位随访时间为 203 个月。在年轻和年老组中，久坐的生活方式加上即使是少量的 AU 也与死亡风险升高相关（均 P<0.05）。在年轻组中，高量 AU 与任何程度的 PA，包括久坐的 PA（HR=2.35，95%CI 1.24-4.44，P=0.009）、低量 PA（HR=1.64，95%CI 1.01-2.68，P=0.047）和中等到剧烈的 PA（HR=1.99，95%CI 1.03-3.84，P=0.041）相结合，与死亡率升高相关。在调整了潜在混杂因素后，这种关系仍然具有统计学意义（均 P<0.05）。在年老组中，中等到剧烈的 PA 与低量 AU 相结合（HR=0.59，95%CI 0.37-0.94，P=0.027）与死亡率降低相关。调整后，中等到剧烈的 PA 与低量 AU 的结合与有利的预后结果独立相关（均 P<0.05）。
在两个年龄组中，久坐的生活方式加上即使是少量的 AU 都是死亡的危险因素。在年轻组中，任何水平的 PA 与高量 AU 相结合与死亡率升高相关。在年老组中，中等到剧烈的 PA 与低量 AU 相结合与死亡率降低相关。
