Gartel' A L, Tikhonenko T I
Mol Biol (Mosk). 1985 May-Jun;19(3):581-96.
The literature devoted to oncogenic action of DNA-containing animal viruses and their role in the development of human neoplasias are reviewed. The regularities of persistence and expression of genetic material of DNA-containing viruses in transformed and tumor cells are comprehensively analyzed. The mechanisms of recombination of cellular and viral DNA during cell transformation as well as the specificity of integration of viral DNA into the host genome are considered. The functions and mechanisms of transforming and tumorigenic action of the products of oncogens of DNA-containing viruses of different groups are discussed. The data on the cell transformation by some DNA-containing viruses without oncogene expression are represented. The mechanism of cell transformation by DNA-containing viruses related to the activation of cellular oncogens is discussed.
本文综述了有关含DNA动物病毒的致癌作用及其在人类肿瘤发生中作用的文献。全面分析了含DNA病毒遗传物质在转化细胞和肿瘤细胞中的持续存在及表达规律。探讨了细胞转化过程中细胞DNA与病毒DNA的重组机制以及病毒DNA整合到宿主基因组中的特异性。讨论了不同组含DNA病毒癌基因产物的转化和致瘤作用的功能及机制。展示了一些无癌基因表达的含DNA病毒导致细胞转化的数据。探讨了含DNA病毒通过激活细胞癌基因实现细胞转化的机制。
