Yi Kyu-Ho
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.
Maylin Clinic (Apgujeong), Seoul, Korea.
J Cosmet Dermatol. 2024 Nov;23(11):3488-3492. doi: 10.1111/jocd.16467. Epub 2024 Jul 9.
The objective of this experiment was to investigate the thermal effects on hyaluronic acid fillers, PCL fillers, and PDO threads when exposed to controlled heat. This study aims to provide insights into how these materials respond to thermal energy, which is crucial for safe and effective cosmetic procedures involving combined modalities.
Cadaveric tissue was utilized to simulate clinical conditions. Hyaluronic acid fillers were injected at approximately 1 mm and 5 mm thicknesses, with variations in G' value (high and low). PCL fillers were similarly injected in 1 mm and 5 mm thicknesses. PDO threads were also inserted. All materials were injected at a depth of 2 cm. A thermometer was used to measure heat penetration, and a multi-wavelength laser was applied to the tissue. The temperature was maintained at 60°C for 5 min to assess whether heat penetrated more than 3 cm in thickness. Observations were made regarding the heat distribution and any physical changes in the fillers and threads.
In thick layers, heat accumulated above the PCL filler without penetrating deeper layers. In thin layers, heat penetration was observed. For the HA fillers, heat energy was not blocked, regardless of the G' value or thickness. For the threads, no significant heat blockage effect was observed. For all materials, no visual changes were detected in any of the materials due to temperature exposure.
The findings suggest that the thickness and composition of fillers significantly influence heat penetration. Thick PCL fillers act as a thermal barrier, whereas thin PCL fillers allow deeper heat penetration. Hyaluronic acid fillers do not impede heat transfer, regardless of their physical properties. PDO threads do not exhibit any notable thermal resistance. These insights are essential for optimizing the safety and efficacy of combined filler and energy-based device treatments in esthetic medicine.
本实验的目的是研究透明质酸填充剂、聚己内酯填充剂和聚对二氧环己酮线在受控加热时的热效应。本研究旨在深入了解这些材料对热能的反应，这对于涉及联合治疗方式的安全有效的美容手术至关重要。
利用尸体组织模拟临床情况。将透明质酸填充剂以约1毫米和5毫米的厚度进行注射，其储能模量（G'值）有高有低。聚己内酯填充剂也以1毫米和5毫米的厚度进行类似注射。还插入了聚对二氧环己酮线。所有材料均在2厘米深度处注射。使用温度计测量热穿透情况，并将多波长激光应用于组织。将温度维持在60°C达5分钟，以评估热穿透厚度是否超过3厘米。观察了填充剂和线的热分布以及任何物理变化。
在厚层中，热量在聚己内酯填充剂上方积聚，未穿透更深层。在薄层中，观察到了热穿透。对于透明质酸填充剂，无论G'值或厚度如何，热能都未被阻挡。对于线，未观察到明显的热阻挡效应。对于所有材料，由于温度暴露，在任何材料中均未检测到视觉变化。
研究结果表明，填充剂的厚度和成分对热穿透有显著影响。厚的聚己内酯填充剂起到热屏障的作用，而薄的聚己内酯填充剂允许更深的热穿透。透明质酸填充剂无论其物理性质如何都不会阻碍热传递。聚对二氧环己酮线未表现出任何显著的热阻。这些见解对于优化美容医学中联合填充剂和基于能量的设备治疗的安全性和有效性至关重要。
