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饮食炎症指数与骨关节炎患者虚弱的关系。

Relationship between dietary inflammation index and frailty in patients with osteoarthritis.

机构信息

Second Ward of Department of Orthopedic Center, The People's Hospital of Feicheng, Shandong, China.

Department of Rehabilitation, Shandong Rehabilitation Hospital, Shandong, China.

出版信息

Ann Hum Biol. 2024 Feb;51(1):2369274. doi: 10.1080/03014460.2024.2369274. Epub 2024 Jul 9.

DOI:10.1080/03014460.2024.2369274
PMID:38979932
Abstract

BACKGROUND

Osteoarthritis (OA) is a common chronic joint disease that significantly affects an individual's quality-of-life and frailty has become one of the common complications in OA patients as the disease progresses. The relationship between dietary patterns is not clear.

METHODS

All participants are from the National Health and Nutrition Examination Survey (NHANES) and have been diagnosed with OA. The dietary inflammation index (DII) is calculated based on the dietary intake reported by the participants. Logistic regression analysis is used to investigate the relationship between DII and frailty. Restricted cubic splines are utilised to explore their nonlinear relationship. Mediation analysis is conducted to explore the role of inflammation in this relationship.

RESULTS

A total of 2,530 OA patients were included in the study, with an average age of 64.46 (12.67) years. After adjusting for covariates, for each one standard deviation increase in DII, the risk of frailty increased by 15% (OR = 1.15, 95% CI = 1.03-1.28). Compared to patients with DII < -1, patients with DII > 1 had a significantly higher risk of frailty (OR = 1.50, 95% CI = 1.05-2.14).

CONCLUSIONS

The findings of this study indicate a positive association between DII and the risk of frailty in OA patients. These results underscore the potential impact of dietary interventions in improving the quality-of-life for OA patients.

摘要

背景

骨关节炎(OA)是一种常见的慢性关节疾病,严重影响个体的生活质量,随着疾病的进展,虚弱已成为 OA 患者的常见并发症之一。饮食模式之间的关系尚不清楚。

方法

所有参与者均来自国家健康和营养检查调查(NHANES),并被诊断为 OA。根据参与者报告的饮食摄入情况计算膳食炎症指数(DII)。采用 logistic 回归分析探讨 DII 与虚弱之间的关系。利用限制立方样条探索它们之间的非线性关系。进行中介分析以探讨炎症在这种关系中的作用。

结果

共纳入 2530 例 OA 患者,平均年龄为 64.46(12.67)岁。调整协变量后,DII 每增加一个标准差,虚弱的风险增加 15%(OR=1.15,95%CI=1.03-1.28)。与 DII<-1 的患者相比,DII>1 的患者虚弱的风险显著增加(OR=1.50,95%CI=1.05-2.14)。

结论

本研究结果表明 DII 与 OA 患者虚弱风险之间存在正相关。这些结果强调了饮食干预在改善 OA 患者生活质量方面的潜在影响。

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