Faix R G, Donn S M
Pediatrics. 1985 Sep;76(3):415-9.
Early-onset group B streptococcal sepsis frequently produces shock in preterm infants, a condition also felt to be contributory to the development of periventricular leukomalacia. During a 2-year study period, 628 preterm infants who were admitted to the neonatal intensive care unit underwent serial sonographic brain scanning; periventricular leukomalacia was diagnosed in eight infants (1.2%). The four infants (100%) who survived group B streptococcal sepsis with septic shock developed periventricular leukomalacia, whereas none of the four survivors (0%) of septic shock caused by other organisms and three of 27 survivors (11%) of shock not caused by infection developed periventricular leukomalacia. Because of the frequency of this lesion, it is suggested that all preterm survivors of group B streptococcal sepsis with septic shock should have serial sonography screening for detection of periventricular leukomalacia. Early detection will not assure cure but may facilitate prognostication, follow-up, and earlier institution of rehabilitative therapy to produce a better outcome.
早发型B族链球菌败血症常导致早产儿休克，这种情况也被认为是脑室周围白质软化症发展的一个促成因素。在一项为期2年的研究期间，628名入住新生儿重症监护病房的早产儿接受了系列脑部超声扫描；8名婴儿（1.2%）被诊断为脑室周围白质软化症。4名（100%）在B族链球菌败血症合并感染性休克中存活下来的婴儿发生了脑室周围白质软化症，而其他病原体所致感染性休克的4名幸存者中无一例（0%）发生脑室周围白质软化症，27名非感染性休克幸存者中有3名（11%）发生脑室周围白质软化症。鉴于这种病变的发生率，建议对所有B族链球菌败血症合并感染性休克的早产幸存者进行系列超声检查，以检测脑室周围白质软化症。早期发现虽不能确保治愈，但可能有助于预后评估、随访以及更早地开展康复治疗以取得更好的结果。
