Yang Chen, Ning Xiao, Wang Baojun, Tian Tian, Chen Yongyan, Ma Le, Wang Linlin
Institute of Reproductive and Child Health/National Health Commission, Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Key Laboratory of Food Quality and Safety for State Market Regulation, National Institute of Food and Drug Control, Beijing 100050, China.
J Hazard Mater. 2024 Sep 5;476:135124. doi: 10.1016/j.jhazmat.2024.135124. Epub 2024 Jul 7.
Exposure to mycotoxins is unavoidable in daily life through ingestion, dermal, and inhalation routes. Toxicological studies found that exposure to mycotoxins might affect male reproductive function. However, there is still a lack of population evidence. We aimed to assess the association of individual and joint exposure to spectrum of mycotoxins with semen quality. The present study included 192 participants in Beijing, China. We measured conventional semen parameters and assessed semen quality. Sixty-seven traditional or emerging mycotoxins were determined to describe the spectrum of mycotoxins. The participants were widely exposed to multiple mycotoxins, and nearly half were simultaneously exposed to more than six mycotoxins. After adjusting potential confounders, logistic regression indicated that the number and concentration of plasma mycotoxin were correlated to the risk of low semen quality. Plasma beauvericin and citrinin concentrations were associated with lower semen quality. The least absolute shrinkage and selection operator regression showed similar results to logistic regression. Quantile-based g-computation and Bayesian kernel machine regression models found that the mixture of mycotoxins was harmful to semen quality, especially in sperm motility. In conclusion, both individual and mixture of mycotoxin exposure were correlated with lower semen quality. More regulations and measures should be taken to reduce mycotoxin contamination.
在日常生活中，通过摄入、皮肤接触和吸入途径不可避免地会接触到霉菌毒素。毒理学研究发现，接触霉菌毒素可能会影响男性生殖功能。然而，目前仍缺乏人群证据。我们旨在评估个体和联合接触多种霉菌毒素与精液质量之间的关联。本研究纳入了中国北京的192名参与者。我们测量了常规精液参数并评估了精液质量。测定了67种传统或新型霉菌毒素以描述霉菌毒素谱。参与者广泛接触多种霉菌毒素，近一半人同时接触六种以上霉菌毒素。在调整潜在混杂因素后，逻辑回归表明血浆霉菌毒素的数量和浓度与精液质量低下的风险相关。血浆中白僵菌素和桔霉素的浓度与较低的精液质量有关。最小绝对收缩和选择算子回归显示出与逻辑回归相似的结果。基于分位数的g计算和贝叶斯核机器回归模型发现，霉菌毒素混合物对精液质量有害，尤其是对精子活力。总之，个体接触和霉菌毒素混合物暴露均与较低的精液质量相关。应采取更多法规和措施以减少霉菌毒素污染。
