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病例报告:多发性转移性原发性耐多药结核脓肿。

Case Report: Multiple Metastatic Primary Multidrug-Resistant Tubercular Abscesses.

机构信息

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Am J Trop Med Hyg. 2024 Jul 9;111(3):526-528. doi: 10.4269/ajtmh.23-0514. Print 2024 Sep 4.

Abstract

This case report presents an atypical manifestation of tuberculosis in a 21-year-old male who presented with multiple subcutaneous swellings in the bilateral heel, left elbow, and base of the left third finger for the previous 6 months. The patient also experienced loss of appetite and unintentional weight loss. Despite initial suspicion of bacterial abscesses, antibiotics did not lead to significant improvement. Further investigations revealed an elevated erythrocyte sedimentation rate and findings suggestive of osteomyelitis on imaging. Gene Xpert testing confirmed multidrug-resistant Mycobacterium tuberculosis as the causative agent. The patient was prescribed a bedaquiline-based multidrug-resistant tuberculosis regimen, which resulted in reduction in swelling size. This report highlights the challenges in diagnosing and managing complex cases of primary multiple tubercular abscesses, especially with drug-resistant strains, emphasizing the importance of timely diagnosis and multidisciplinary management for successful outcomes.

摘要

本病例报告呈现了一位 21 岁男性的非典型结核病表现,他在过去 6 个月中出现双侧脚跟、左肘和左手第三指基部的多个皮下肿块,同时伴有食欲不振和非自愿性体重减轻。尽管最初怀疑为细菌性脓肿,但抗生素治疗并未显著改善症状。进一步的检查显示红细胞沉降率升高,影像学检查提示骨髓炎。Gene Xpert 检测证实了导致疾病的病原体为多药耐药结核分枝杆菌。患者接受了以贝达喹啉为基础的多药耐药结核病治疗方案,结果肿胀大小有所减小。本报告强调了诊断和管理原发性多发性结核脓肿复杂病例的挑战,尤其是耐药菌株,强调了及时诊断和多学科管理对于获得成功结果的重要性。

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