Van der Zee H, Bizios R, Malik A B
Respir Physiol. 1985 Jul;61(1):31-42. doi: 10.1016/0034-5687(85)90026-x.
We examined the consequences of high frequency ventilation (HFV) on pulmonary lymph flow (Qlym) in normal lungs and after the lymph flow was increased with an i.v. histamine infusion (2 micrograms/kg/min). Studies were made in the anesthetized sheep prepared with lung lymph fistulas. The sheep were subjected to intermittent positive pressure ventilation (IPPV) (frequency (f) = 12 breaths/min, tidal volume (TV) = 10 ml/kg) and HFV (f = 7 Hz, TV = 1-2 ml/kg). TV was adjusted prior to the experiment to achieve normal arterial blood gases. Histamine infusion doubled Qlym and lymph protein clearance (Qlym X lymph-to-plasma protein concentration ratio) from baseline. HFV did not affect Qlym and lymph protein clearance in normal lungs or after histamine infusion. HFV also did not result in generation of thromboxane (TxA2) and prostacyclin because plasma concentrations of their stable degradation products, TxB2 and 6-ketoprostaglandin F1 alpha, were not significantly elevated. The results indicate that HFV does not alter lymphatic pumping in the normal lung and during increased transcapillary protein transport.
我们研究了高频通气（HFV）对正常肺脏以及静脉输注组胺（2微克/千克/分钟）使淋巴流量增加后的肺淋巴流量（Qlym）的影响。研究在制备了肺淋巴瘘的麻醉绵羊身上进行。绵羊接受间歇正压通气（IPPV）（频率（f）=12次/分钟，潮气量（TV）=10毫升/千克）和高频通气（f = 7赫兹，TV = 1 - 2毫升/千克）。在实验前调整潮气量以实现正常的动脉血气。输注组胺使Qlym和淋巴蛋白清除率（Qlym×淋巴与血浆蛋白浓度比）从基线水平翻倍。高频通气在正常肺脏或输注组胺后均未影响Qlym和淋巴蛋白清除率。高频通气也未导致血栓素（TxA2）和前列环素的生成，因为它们稳定降解产物血浆浓度，即血栓素B2（TxB2）和6 - 酮前列腺素F1α，并未显著升高。结果表明，高频通气在正常肺脏以及跨毛细血管蛋白转运增加期间不会改变淋巴泵功能。
