Jose R. Reyes Memorial Medical Center, Manila, Philippines.
J Cutan Pathol. 2024 Oct;51(10):773-776. doi: 10.1111/cup.14688. Epub 2024 Jul 9.
Cutaneous metastasis is rare but may indicate an advanced internal malignancy or a recurrence of a previously treated one and is usually associated with a poor prognosis. They may also pose a diagnostic problem as the clinical manifestations are variable and non-specific, which could mimic other benign conditions. We report a case of a 48-year-old female who presented with a 4-year history of erythematous papules and vesicles on the trunk mimicking lymphangioma circumscriptum. Skin biopsy and immunohistochemistry were consistent with cutaneous metastasis from breast carcinoma. Cutaneous metastasis presents in a variety of patterns. A high index of suspicion and a low threshold for skin biopsy are paramount to the early diagnosis and treatment. A histopathologic evaluation will help identify the origin of the cutaneous metastasis and can significantly affect the outcome of the treatment.
皮肤转移较为罕见,但可能表明存在内部恶性肿瘤的进展或先前治疗过的肿瘤的复发,且通常与预后不良相关。它们也可能带来诊断问题,因为临床表现多变且无特异性,可能与其他良性疾病相混淆。我们报告了一例 48 岁女性病例,其 4 年来躯干上出现红斑性丘疹和水疱,类似于淋巴管瘤。皮肤活检和免疫组化检查结果与乳腺癌皮肤转移一致。皮肤转移的表现形式多种多样。对皮肤活检保持高度怀疑和低门槛至关重要,这有助于早期诊断和治疗。组织病理学评估将有助于确定皮肤转移的来源,并显著影响治疗结果。