代谢综合征与亚临床甲状腺功能减退症风险的关系：系统评价和荟萃分析。
Metabolic syndrome and risk of subclinical hypothyroidism: a systematic review and meta-analysis.
机构信息
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
出版信息
Front Endocrinol (Lausanne). 2024 Jun 25;15:1399236. doi: 10.3389/fendo.2024.1399236. eCollection 2024.
BACKGROUND
Subclinical hypothyroidism (SCH) is a common endocrine subclinical disorder, the main adverse consequences of which are the development of clinical hypothyroidism and the promotion of ischemic heart disease. Metabolic syndrome (MetS) is a collection of metabolic problems. The goal of this meta-analysis was to evaluate the relationship between MetS and SCH.
METHODS
Suitable publications were identified using PubMed, Embase, and the Cochrane Library. The meta-analysis included only studies in English that reported odds ratio (OR) data for MetS and SCH. Two researchers combined data using a random-effects model. OR and 95% confidence intervals (CIs) were used to present the results.
RESULTS
MetS was associated with an elevated risk of developing SCH (OR 2.56, 95% CI 1.44-4.55). However, the individual components of MetS were not associated with the risk of SCH. Subgroup analysis revealed that different definitions of MetS had varying effects on SCH. Sensitivity analysis confirmed that our results were robust.
CONCLUSIONS
This meta-analysis indicates that patients with MetS have an increased risk of SCH, while there is no significant association between the five individual components of MetS and the risk of SCH.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023454415.
背景
亚临床甲状腺功能减退症（SCH）是一种常见的内分泌亚临床疾病，其主要不良后果是发展为临床甲状腺功能减退症和促进缺血性心脏病。代谢综合征（MetS）是一组代谢问题。本荟萃分析的目的是评估 MetS 与 SCH 之间的关系。
方法
使用 PubMed、Embase 和 Cochrane 图书馆确定合适的出版物。荟萃分析仅包括以英文报告 MetS 和 SCH 比值比（OR）数据的研究。两位研究人员使用随机效应模型合并数据。使用 OR 和 95%置信区间（CI）表示结果。
结果
MetS 与发生 SCH 的风险增加相关（OR 2.56，95%CI 1.44-4.55）。然而，MetS 的各个组成部分与 SCH 的风险无关。亚组分析表明，MetS 的不同定义对 SCH 的影响不同。敏感性分析证实我们的结果是稳健的。
结论
这项荟萃分析表明，患有 MetS 的患者发生 SCH 的风险增加，而 MetS 的五个个体组成部分与 SCH 的风险之间没有显著关联。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO/，标识符 CRD42023454415。
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