Sawant Abhilash, Saha Aindrila, Khoussine Jacob, Sinha Raunak, Hoon Mrinalini
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
Front Ophthalmol (Lausanne). 2023 Apr 20;3:1168548. doi: 10.3389/fopht.2023.1168548. eCollection 2023.
The retinal neural circuit is intricately wired for efficient processing of visual signals. This is well-supported by the specialized connections between retinal neurons at both the functional and ultrastructural levels. Through 3D electron microscopic (EM) reconstructions of retinal neurons and circuits we have learnt much about the specificities of connections within the retinal layers including new insights into how retinal neurons establish connections and perform sophisticated visual computations. This mini-review will summarize the retinal circuitry and provide details about the novel insights EM connectomics has brought into our understanding of the retinal circuitry. We will also discuss unresolved questions about the retinal circuitry that can be addressed by EM connectomics in the future.
视网膜神经回路以复杂的方式连接，用于高效处理视觉信号。视网膜神经元在功能和超微结构水平上的特殊连接充分支持了这一点。通过对视网膜神经元和回路进行三维电子显微镜（EM）重建，我们对视网膜各层内连接的特异性有了很多了解，包括对视网膜神经元如何建立连接以及执行复杂视觉计算的新见解。这篇小型综述将总结视网膜回路，并详细介绍EM连接组学为我们理解视网膜回路带来的新见解。我们还将讨论关于视网膜回路的未解决问题，这些问题未来可通过EM连接组学来解决。
