Djurić D S, Djordjević P B, Micić D D
Endocrinologie. 1985 Apr-Jun;23(2):111-4.
The aim of the study was to compare the strength of action, the timing of maximal effect and duration of hypoglycaemic effect of biosynthetic human insulin compared to conventional bovine short acting insulin. On that purpose, a modified insulin tolerance test was performed in 10 healthy persons, first with bovine (Kristalni Insulin-Galenika) and a week later, with a biosynthetic human (Bio.-Human Insulin-Lilly) insulin in a dose of 0.15 U/kg body weight. The blood samples for estimation of glycaemia (glucose oxidase method) were collected at 0, 5, 10, 15, 20, 25, 30, 40, 50, 60, 90 and 120 minutes. Comparing the degree of hypoglycaemia, the time of its beginning and its duration, it is concluded that there was no statistically significant difference between biosynthetic human and conventional short acting bovine insulin used in a single dose in healthy persons.
本研究的目的是比较生物合成人胰岛素与传统牛短效胰岛素的作用强度、最大效应时间及降血糖作用持续时间。为此，对10名健康人进行了改良胰岛素耐量试验，先使用牛胰岛素（Kristalni Insulin - Galenika），一周后使用生物合成人胰岛素（Bio.-Human Insulin - Lilly），剂量均为0.15 U/kg体重。在0、5、10、15、20、25、30、40、50、60、90和120分钟采集血样以测定血糖（葡萄糖氧化酶法）。比较低血糖程度、开始时间及持续时间后得出结论，在健康人中单次使用生物合成人胰岛素和传统短效牛胰岛素之间无统计学显著差异。
