Du Xian, Hu Jun, Xue Jianhua, Zhuang Yuan, Tang Xuefeng, Xu Zhiyue
Health Examination Center, Shanghai Health and Medical Center (Huadong Sanatorium), Wuxi, People's Republic of China.
The Affiliated Hospital of Nantong University, Nantong, People's Republic of China.
Int J Gen Med. 2024 Jul 4;17:2945-2953. doi: 10.2147/IJGM.S466980. eCollection 2024.
Fatigue was a common symptom of non-alcoholic fatty liver disease (NAFLD), which seriously affected patients' quality of life. The aim of this study was to detect fatigue rate and to evaluate factors associated with fatigue in NAFLD patients.
A cross-sectional study was carried out from the Huadong Sanatorium between April 2022 and May 2023, and 133 NAFLD patients were included in this study. They completed Fatigue Severity Scale to assess fatigue, the Hospital Anxiety and Depression Scale to estimate psychological status, and the Pittsburgh Sleep Quality Index for sleep quality. Data were analyzed by independent samples -tests, χ2 tests and logistic regression models.
We found that 51.1% of NAFLD patients had fatigue. Exercise, anxiety, depression, subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disorders, daytime dysfunction and overall sleep quality were related to fatigue among NAFLD patients. Moreover, logistic regression models indicated anxiety, habitual sleep efficiency and sleep disorders as important predictors of fatigue.
This was the first time to explore demographic, clinical, psychological and sleeping correlated factors for fatigue in Chinese NAFLD patients. Our study showed that more than half of NAFLD patients had fatigue, and anxiety, habitual sleep efficiency and sleep disorders were significantly associated with fatigue in NAFLD. The findings indicated that it was very necessary to pay more attention to fatigue of NAFLD patients, especially those with negative emotions and poor sleep quality by favorable intervention to relieve fatigue symptoms, so as to improve quality of life.
疲劳是非酒精性脂肪性肝病（NAFLD）的常见症状，严重影响患者的生活质量。本研究旨在检测NAFLD患者的疲劳发生率，并评估与疲劳相关的因素。
于2022年4月至2023年5月在华东疗养院开展一项横断面研究，本研究纳入了133例NAFLD患者。他们完成了疲劳严重程度量表以评估疲劳，医院焦虑抑郁量表以评估心理状态，以及匹兹堡睡眠质量指数以评估睡眠质量。数据采用独立样本t检验、χ²检验和逻辑回归模型进行分析。
我们发现51.1%的NAFLD患者存在疲劳。运动、焦虑、抑郁、主观睡眠质量、睡眠潜伏期、睡眠时间、习惯性睡眠效率、睡眠障碍、日间功能障碍和总体睡眠质量与NAFLD患者的疲劳相关。此外，逻辑回归模型表明焦虑、习惯性睡眠效率和睡眠障碍是疲劳的重要预测因素。
这是首次在中国NAFLD患者中探讨与疲劳相关的人口统计学、临床、心理和睡眠相关因素。我们的研究表明，超过一半的NAFLD患者存在疲劳，且焦虑、习惯性睡眠效率和睡眠障碍与NAFLD患者的疲劳显著相关。研究结果表明，非常有必要更加关注NAFLD患者的疲劳，尤其是那些有负面情绪和睡眠质量差的患者，通过适当干预缓解疲劳症状，从而提高生活质量。
