Du Xian, Zhao Qian, Zhuang Yuan, Chen Haoyang, Shen Biyu
Department of Nursing, The Second Affiliated Hospital of Nantong University, Nantong, China,
School of Nursing, Nantong University, Nantong, China,
Patient Prefer Adherence. 2018 Sep 6;12:1729-1735. doi: 10.2147/PPA.S170984. eCollection 2018.
Fatigue is a very common symptom of systemic lupus erythematosus (SLE), which significantly impairs patients' quality of life. The purpose of this study is to evaluate contributors of fatigue and effects of fatigue on the quality of life in Chinese SLE patients.
A survey of 119 SLE patients using the Fatigue Severity Scale (FSS) to assess the severity of fatigue was carried out. SLE patients completed the Systemic Lupus Erythematosus Disease Activity Index, the Hospital Anxiety and Depression Scale, the Short Form 36 health survey and the Pittsburgh Sleep Quality Index. Meanwhile, 105 healthy individuals completed FSS, the Hospital Anxiety and Depression Scale and Short Form 36 health survey. We used chi-squared analysis, independent samples -tests and logistic regression models to analyze data.
Our results found that the FSS score of patients with SLE was higher than that of healthy controls. The disease duration, anxiety, depression, subjective sleep quality and sleep disorders significantly correlated with fatigue in SLE patients. Moreover, logistic regression models showed depression and sleep disorders as predictors of fatigue. In SLE patients, fatigued patients had lower quality of life than those who were non-fatigued.
This is the first time to explore contributors of fatigue and the influence of fatigue on SLE patients' quality of life in China. Our study showed that depression and sleep disorders were predictors of fatigue, and fatigue seriously damaged SLE patients' quality of life. The results indicate that it is necessary to conduct holistic assessment and effective intervention, such as systemic psychiatric screening, psychological care and practical sleep guidance, to relieve symptoms of fatigue and finally improve their quality of life in SLE patients.
疲劳是系统性红斑狼疮（SLE）非常常见的症状，严重损害患者的生活质量。本研究旨在评估中国SLE患者疲劳的影响因素以及疲劳对生活质量的影响。
对119例SLE患者进行调查，使用疲劳严重程度量表（FSS）评估疲劳的严重程度。SLE患者完成系统性红斑狼疮疾病活动指数、医院焦虑抑郁量表、简明健康调查问卷36项和匹兹堡睡眠质量指数。同时，105名健康个体完成FSS、医院焦虑抑郁量表和简明健康调查问卷36项。我们使用卡方分析、独立样本t检验和逻辑回归模型分析数据。
我们的研究结果发现，SLE患者的FSS评分高于健康对照组。病程、焦虑、抑郁、主观睡眠质量和睡眠障碍与SLE患者的疲劳显著相关。此外，逻辑回归模型显示抑郁和睡眠障碍是疲劳的预测因素。在SLE患者中，疲劳患者的生活质量低于非疲劳患者。
这是首次在中国探索SLE患者疲劳的影响因素以及疲劳对其生活质量的影响。我们的研究表明，抑郁和睡眠障碍是疲劳的预测因素，疲劳严重损害SLE患者的生活质量。结果表明，有必要对SLE患者进行全面评估和有效干预，如系统的精神筛查、心理护理和切实可行的睡眠指导，以缓解疲劳症状，最终提高他们的生活质量。
