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一组不寻常的IgA血管炎病例系列

A Case Series of Unusual IgA Vasculitis.

作者信息

Bradley Jared, Whitaker Ian, Lyons Brittany, Mangla Amy

机构信息

Trident Medical Center, Charleston, SC.

出版信息

HCA Healthc J Med. 2024 Apr 30;5(2):157-164. doi: 10.36518/2689-0216.1627. eCollection 2024.

Abstract

INTRODUCTION

Immunoglobulin A vasculitis (IgA)is a rare condition characterized by palpable purpura, often involving the skin, gastrointestinal tract, joints, and kidneys. Presentation is usually acute and is more common in children and adolescents of Southeast Asian and European descent. In the adult population, it is less common and therapies are not as well-established.

CASE PRESENTATION

Disease prevalence of IgA vasculitis outside Southeast Asian and European populations is not well-documented. In this case series, we present 2 cases of IgA vasculitis in 2 older adult males, one of Native American descent and one of African American descent.

CONCLUSION

IgA vasculitis must be considered within the adult population, and it is not limited to certain ethnic groups. Further research is needed to give clarity on the best treatment options for adults with IgA vasculitis. We believe that patients presenting with IgA vasculitis are best managed in a multidisciplinary approach, especially those patients with limited improvement despite the initiation of corticosteroids. Our 2 cases should raise awareness of IgA vasculitis in patients with skin rashes and elevated creatinine levels.

摘要

引言

免疫球蛋白A血管炎(IgA)是一种罕见疾病,其特征为可触及的紫癜,常累及皮肤、胃肠道、关节和肾脏。发病通常较急,在东南亚和欧洲裔儿童及青少年中更为常见。在成人中,该病较为少见,治疗方法也尚未完全确立。

病例报告

东南亚和欧洲人群以外的IgA血管炎疾病患病率尚无充分文献记载。在本病例系列中,我们报告了2例老年男性IgA血管炎病例,其中1例为美洲原住民后裔,另1例为非裔美国人后裔。

结论

成人人群中必须考虑IgA血管炎,且该病并不局限于特定种族群体。需要进一步研究以明确成人IgA血管炎的最佳治疗方案。我们认为,IgA血管炎患者最好采用多学科方法进行管理,尤其是那些尽管开始使用皮质类固醇但改善有限的患者。我们的2例病例应提高对皮疹和肌酐水平升高患者中IgA血管炎的认识。

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