氟轻松在润肤霜基质中的多中心试验。

Multicenter trial of fluocinonide in an emollient cream base.

作者信息

Fisher M, Kelly A P

出版信息

Int J Dermatol. 1979 Oct;18(8):660-4. doi: 10.1111/j.1365-4362.1979.tb04686.x.

DOI:10.1111/j.1365-4362.1979.tb04686.x

Abstract

Working independently, eight investigators evaluated the clinical effectiveness of fluocinonide 0.05% in a three-week double-blind paired comparison trial of 240 patients. Half the investigators compared fluocinonide emollient cream with betamethasone valerate 0.1% cream in the treatment of atopic dermatitis, while the remaining four compared the study drug with triamcinolone acetonide 0.1% cream in the treatment of psoriasis. Statistical analysis showed clinical responses favored fluocinonide p = 0.021 (Wilcoxon Signed Rank) for the atopic dermatitis group and p = 0.001 (Wilcoxon Signed Rank) for the psoriasis group.

摘要

八名研究人员独立开展工作，在一项针对240名患者的为期三周的双盲配对比较试验中，评估了0.05%氟轻松的临床疗效。一半的研究人员将氟轻松润肤霜与0.1%戊酸倍他米松乳膏用于治疗特应性皮炎进行比较，而其余四人则将受试药物与0.1%曲安奈德乳膏用于治疗银屑病进行比较。统计分析显示，对于特应性皮炎组，临床反应更倾向于氟轻松（Wilcoxon符号秩检验，p = 0.021）；对于银屑病组，临床反应更倾向于氟轻松（Wilcoxon符号秩检验，p = 0.001）。