Gideon Angelina, von Känel Roland, Degroote Cathy, Thomas Livia, Zuccarella-Hackl Claudia, Wiest Roland, Wirtz Petra H
Biological Work and Health Psychology, University of Konstanz, Konstanz, Germany.
Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Front Cardiovasc Med. 2024 Jun 25;11:1335329. doi: 10.3389/fcvm.2024.1335329. eCollection 2024.
While aldosterone plays an important role in blood pressure regulation, its role in essential hypertension (EHT) remains unclear. Here, we systematically investigated the secretion of biologically-active free aldosterone in saliva in response to awakening (AldAR) and during the day (AldDay) in EHT compared to normotensive controls (NT).
In 30 men with EHT and 30 age-matched NT, AldAR saliva samples were collected immediately after awakening and 15, 30, 45, and 60 min thereafter and AldDay samples were collected from 08:30-22:00 h on two consecutive days.
Over the course of the day, men with EHT had higher repeated AldDay levels compared to NT (=.002) with higher concentrations in the morning hours ('s ≤ .047), a steeper decline over the course of the day ('s ≤ .018), and similar concentrations in the evening ('s ≥ .21). Regarding AldAR, we observed higher concentrations in EHT at awakening (=.017) and borderline higher concentrations at 15 min (=.086). No differences were found 30-60 min after awakening ('s ≥ .34). Analyses with repeated and aggregated AldAR levels resulted in borderline significantly higher free aldosterone in EHT ('s ≤ .077). Complementary analyses confirmed linear associations between higher blood pressure and higher AldAR and AldDay levels.
Our data point to elevated salivary free aldosterone secretion in EHT over the course of the day, particularly in the morning hours. As the free aldosterone fraction is considered biologically active, our data may point to a biological mechanism underlying EHT.
虽然醛固酮在血压调节中起重要作用，但其在原发性高血压（EHT）中的作用仍不清楚。在此，我们系统地研究了与血压正常的对照组（NT）相比，EHT患者在觉醒时（AldAR）及白天（AldDay）唾液中生物活性游离醛固酮的分泌情况。
选取30名EHT男性患者和30名年龄匹配的NT男性，在觉醒后立即采集AldAR唾液样本，并在随后的15、30、45和60分钟采集样本；在连续两天的08:30至22:00采集AldDay样本。
在一天中，EHT男性患者的AldDay水平反复高于NT患者（P = 0.002），上午浓度更高（P≤0.047），一天中下降更陡峭（P≤0.018），晚上浓度相似（P≥0.21）。关于AldAR，我们观察到EHT患者觉醒时浓度较高（P = 0.017），15分钟时浓度略高（P = 0.086）。觉醒后30 - 60分钟未发现差异（P≥0.34）。对重复和汇总的AldAR水平进行分析，结果显示EHT患者游离醛固酮略显著更高（P≤0.077）。补充分析证实血压升高与更高的AldAR和AldDay水平之间存在线性关联。
我们的数据表明，EHT患者在一天中唾液游离醛固酮分泌升高，尤其是在上午。由于游离醛固酮部分被认为具有生物活性，我们的数据可能指向EHT潜在的生物学机制。
