Burton G H, Seed W A, Vernon P
Thorax. 1985 Jul;40(7):519-25. doi: 10.1136/thx.40.7.519.
A previously reported computer analysis has been used to provide numerical ventilation-perfusion lung scan data, for comparison with tests of airways function and results of arterial blood gas analysis in 11 patients with pulmonary embolism, 18 with asthma, and 37 with chronic obstructive lung disease. In pulmonary embolism an index of underperfusion showed high sensitivity, and an index of ventilation-perfusion mismatching correlated well with severity (hypoxaemia). In asthma an index of underventilation was sensitive and correlated well with severity of airways obstruction. In chronic obstructive lung disease the same index was sensitive but correlated poorly with severity. This was attributed to heterogeneity of the lung disease (airways obstruction plus emphysema) in chronic obstructive lung disease. Ventilation-perfusion mismatching was frequently present in airways disease, and was often of great severity in chronic obstructive lung disease. Discrimination between pulmonary embolism and either type of airways disease was possible by using a combination of underfusion and underventilation indices. The technique offers the prospect of increasing the information derived from lung scans and of automating the reporting of scans.
一项先前报道的计算机分析已被用于提供肺通气灌注扫描的数值数据，以与11例肺栓塞患者、18例哮喘患者和37例慢性阻塞性肺疾病患者的气道功能测试及动脉血气分析结果进行比较。在肺栓塞中，灌注不足指数显示出高敏感性，通气-灌注不匹配指数与严重程度（低氧血症）密切相关。在哮喘中，通气不足指数敏感且与气道阻塞严重程度密切相关。在慢性阻塞性肺疾病中，相同指数敏感但与严重程度相关性较差。这归因于慢性阻塞性肺疾病中肺部疾病（气道阻塞加肺气肿）的异质性。通气-灌注不匹配在气道疾病中经常出现，在慢性阻塞性肺疾病中往往非常严重。通过结合灌注不足和通气不足指数，可以区分肺栓塞与任何一种气道疾病。该技术有望增加从肺部扫描获得的信息并实现扫描报告的自动化。
