Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
J Obstet Gynaecol. 2024 Dec;44(1):2371956. doi: 10.1080/01443615.2024.2371956. Epub 2024 Jul 10.
Neurological disorders are common in preterm (PT) born individuals. Diffusion tensor imaging (DTI) studies using tract-based spatial statistics (TBSS) effectively detect microstructural white matter (WM) abnormalities in the brain. We conducted this systematic review to integrate the findings of TBSS studies to determine the most consistent WM alterations in PT born individuals.
PubMed, Embase, Web of Science and Science Direct were searched. DTI studies using TBSS in PT born individuals were screened up to October 2022. The systematic review included studies reporting alterations in FA values for the entire brain in a stereotactic space, with three coordinates (x, y, z), according to the seed-based d mapping method.
The search strategy identified seventeen studies that fulfilled our inclusion criteria, with a total of 911 PT-born individuals and 563 matched controls were analysed. Of the seventeen studies, eight were dedicated to 650 adults, five to 411 children and four to 413 infants. Ten studies recruited 812 individuals born very prematurely (GA <29 weeks), six studies recruited 386 moderately premature individuals (GA = 29-32 weeks) and one study recruited 276 individuals born late prematurely (GA >32 weeks). This meta-analysis of six studies including 388 individuals highlighted four brain regions in which fractional anisotropy (FA) was lower in PT group than in people born at term. The quantitative meta-analysis found that the most robust WM alterations were located in the corpus callosum (CC), the bilateral thalamus and the left superior longitudinal fasciculus (SLF) II. Significant changes in FA reflect WM abnormalities in PT born individuals from infant to young adulthood.
Significant changes in FA reflect WM abnormalities in individuals born PT from infancy to young adulthood. The abnormal development of the CC, bilateral thalamus and left SLF may play a vital role in the neurodevelopment of PT individuals.
早产（PT）出生的个体中常见神经障碍。基于束的空间统计（TBSS）的弥散张量成像（DTI）研究有效地检测大脑中的微观结构白质（WM）异常。我们进行了这项系统综述，以整合 TBSS 研究的结果，确定 PT 出生个体中最一致的 WM 改变。
我们检索了 PubMed、Embase、Web of Science 和 Science Direct。截至 2022 年 10 月，筛选了使用 TBSS 的 PT 出生个体的 DTI 研究。系统综述包括报告了整个大脑 FA 值改变的研究，这些研究是在立体定向空间中，根据基于种子的 d 映射方法，有三个坐标（x，y，z）。
搜索策略确定了符合纳入标准的 17 项研究，共有 911 名 PT 出生个体和 563 名匹配对照者进行了分析。在这 17 项研究中，8 项专门针对 650 名成年人，5 项针对 411 名儿童，4 项针对 413 名婴儿。10 项研究招募了 812 名非常早产（GA<29 周）的个体，6 项研究招募了 386 名中度早产（GA=29-32 周）的个体，1 项研究招募了 276 名晚期早产（GA>32 周）的个体。这项包括 388 名个体的 6 项研究的荟萃分析强调了四个大脑区域，在这些区域中，PT 组的分数各向异性（FA）值低于足月出生的个体。定量荟萃分析发现，最明显的 WM 改变位于胼胝体（CC）、双侧丘脑和左侧上纵束（SLF） II。FA 的显著变化反映了 PT 出生个体从婴儿期到成年早期的 WM 异常。
FA 的显著变化反映了 PT 出生个体从婴儿期到成年早期的 WM 异常。胼胝体、双侧丘脑和左侧 SLF 的异常发育可能在 PT 个体的神经发育中发挥重要作用。
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