Opelz G
Transplantation. 1985 Sep;40(3):240-3. doi: 10.1097/00007890-198509000-00003.
In a series of more than 8000 first cadaver transplants performed during a two-year period, 2198 recipients treated with cyclosporine had a higher graft survival rate (76 +/- 1% at 1 year) than 6392 recipients without cyclosporine (64 +/- 1%, P less than 0.0001). Matching for HLA-B plus HLA-DR resulted in a significant correlation with graft outcome, in patients with or without cyclosporine treatment (P less than 0.0001). Regardless of whether cyclosporine was used or not, grafts with 0 HLA-B,-DR incompatibilities had approximately 20% higher success rates at one year than grafts with 4 mismatches. A high (86 +/- 3%) graft survival rate was obtained in 161 cyclosporine-treated recipients with 0 HLA-B,-DR mismatches. Matching for the HLA-B and HLA-DR loci is shown to have an additive effect in cadaver kidney transplantation.
在为期两年的一系列超过8000例首次尸体移植中，2198例接受环孢素治疗的受者的移植肾存活率（1年时为76±1%）高于6392例未接受环孢素治疗的受者（64±1%，P<0.0001）。在接受或未接受环孢素治疗的患者中，HLA - B加HLA - DR配型与移植结果显著相关（P<0.0001）。无论是否使用环孢素，HLA - B、 - DR不匹配数为0的移植肾在1年时的成功率比不匹配数为4的移植肾高出约20%。161例接受环孢素治疗且HLA - B、 - DR不匹配数为0的受者获得了较高（86±3%）的移植肾存活率。HLA - B和HLA - DR位点的配型在尸体肾移植中显示出累加效应。
