HLA-DR配型在多次输血的尸体肾移植受者中的重要性。一项前瞻性单中心研究。

Importance of HLA-DR matching in polytransfused cadaveric kidney transplant recipients. A prospective one-center study.

作者信息

Vanrenterghem Y, Vandeputte I, Lerut T, Roels L, Gruwez J, Michielsen P

出版信息

Transplantation. 1983 Oct;36(4):384-7. doi: 10.1097/00007890-198310000-00007.

DOI:10.1097/00007890-198310000-00007

Abstract

Since August 1978 prospective HLA-DR typing has been performed in 157 donor-recipient pairs. All recipients received pretransplant blood transfusions. This study shows that HLA-DR matching can significantly improve the survival of cadaveric kidney allografts, even in polytransfused recipients. Patients receiving kidneys with no HLA-DR incompatibilities have a one-year graft survival of 97%, versus 86% for recipients with 1 HLA-DR incompatibility and 73% for recipients with 2 HLA-DR incompatibilities. The cumulative dose of corticosteroids during the first year after transplantation is significantly lower in patients with no DR-incompatibilities. HLA-A and B matching have no additional effect on graft survival.

摘要

自1978年8月起，对157对供体 - 受体进行了前瞻性HLA - DR分型。所有受体在移植前均接受输血。本研究表明，即使在多次输血的受体中，HLA - DR配型也能显著提高尸体肾移植的存活率。接受无HLA - DR不相容肾脏的患者，其移植肾一年存活率为97%，而有1个HLA - DR不相容的受体为86%，有2个HLA - DR不相容的受体为73%。移植后第一年，无DR不相容的患者使用皮质类固醇的累积剂量显著更低。HLA - A和B配型对移植肾存活无额外影响。