Wei Jinwen, Gao Can, Lu Changxu, Wang Lijie, Dong Dan, Sun Mingli
College of Exercise and Health, Shenyang Sport University, No.36 Jinqiansong East Road, Shenyang, 110102, Liaoning, People's Republic of China.
Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110033, Liaoning, People's Republic of China.
Mol Cell Biochem. 2025 Feb;480(2):825-839. doi: 10.1007/s11010-024-05063-4. Epub 2024 Jul 10.
Cardiomyopathies are a group of heterogeneous diseases, characterized by abnormal structure and function of the myocardium. For many years, it has been a hot topic because of its high morbidity and mortality as well as its complicated pathogenesis. The E2Fs, a group of transcription factors found extensively in eukaryotes, play a crucial role in governing cell proliferation, differentiation, and apoptosis, meanwhile their deregulated activity can also cause a variety of diseases. Based on accumulating evidence, E2Fs play important roles in cardiomyopathies. In this review, we describe the structural and functional characteristics of the E2F family and its role in cardiomyocyte processes, with a focus on how E2Fs are associated with the onset and development of cardiomyopathies. Moreover, we discuss the great potential of E2Fs as biomarkers and therapeutic targets, aiming to provide a reference for future research.
心肌病是一组异质性疾病，其特征是心肌结构和功能异常。多年来，由于其高发病率和死亡率以及复杂的发病机制，它一直是一个热门话题。E2F 是一组在真核生物中广泛发现的转录因子，在调控细胞增殖、分化和凋亡中起关键作用，同时其活性失调也会导致多种疾病。基于越来越多的证据，E2F 在心肌病中发挥重要作用。在本综述中，我们描述了 E2F 家族的结构和功能特征及其在心肌细胞过程中的作用，重点关注 E2F 如何与心肌病的发生和发展相关联。此外，我们讨论了 E2F 作为生物标志物和治疗靶点的巨大潜力，旨在为未来的研究提供参考。
