Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Urology, The University of Texas Health Science Centre at San Antonio, San Antonio, TX, USA.
World J Urol. 2024 Jul 10;42(1):394. doi: 10.1007/s00345-024-05074-2.
Precision Prostatectomy (PP) is a viable treatment option for men with unilateral dominant cancer who are interested in preserving functional outcomes. To date, the data published about the outcomes of this technique has come from a single center only (Henry Ford - HF). We present the surgical, functional, and oncological outcomes of the first series of patients to undergo PP outside of HF, to demonstrate the safety and reproducibility of the technique.
Between 2022 and 2023, PP was offered to select patients who were interested in preserving their functional status. Men who underwent PP were followed at 3 monthly intervals; information regarding their functional status was simultaneously obtained. Men who had biochemical recurrence were advised to undergo remnant biopsy. If residual cancer was detected, then remnant removal was performed.
The median age and median PSA of the study group was 63 years and 6.89 ng/ml respectively. The median operative and console times were 196.5 and 154 minutes. No intra-operative complications were noted. Three patients had a total of three post-operative complications. Three patients had biochemical recurrence; cancer was not detected in any of these patients on postoperative biopsies of the prostatic remnant. At 12 months, 91% of patients reported using 0 pads/day and 90.9% of pre-operatively potent patients were potent at 12 months.
PP is a safe and reproducible technique that can ensure cancer control and preservation of functional status in select patients. Further studies with large sample sizes and longer follow-up are required to ascertain the long-term outcomes of this surgical technique.
精准前列腺切除术 (PP) 是一种可行的治疗选择,适用于对保留功能结果感兴趣的单侧优势型癌症男性。迄今为止,关于该技术结果的已发表数据仅来自一个中心(亨利福特 - HF)。我们介绍了第一批在 HF 以外接受 PP 的患者的手术、功能和肿瘤学结果,以证明该技术的安全性和可重复性。
在 2022 年至 2023 年间,向有兴趣保留其功能状态的患者提供 PP。接受 PP 的男性每 3 个月随访一次;同时获得他们的功能状态信息。有生化复发的男性建议进行残留活检。如果发现残留癌症,则进行残留切除。
研究组的中位年龄和中位 PSA 分别为 63 岁和 6.89ng/ml。中位手术和控制台时间分别为 196.5 分钟和 154 分钟。没有术中并发症。3 名患者共发生 3 例术后并发症。3 名患者有生化复发;在前列腺残留的术后活检中,这些患者均未发现癌症。12 个月时,91%的患者报告每天使用 0 个尿垫,90.9%的术前有能力的患者在 12 个月时仍有能力。
PP 是一种安全且可重复的技术,可以确保在选择的患者中控制癌症并保留功能状态。需要进一步进行具有更大样本量和更长随访时间的研究,以确定该手术技术的长期结果。